Author

L. Mei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Bioengineering· 3 Biophysics· 2 Plant Biology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 12 Research Focus:cell type annotation· 6 Research Focus:cell signaling & trafficking· 5 Organism:human· 5 Research Focus:differential expression· 4 Research Focus:drug response / drug discovery· 4 Approach:deep learning· 3 Research Focus:host-pathogen & immune response· 3

Frequent Co-Authors

A. Baker· 2 shared A. Sligar· 2 shared E. Takematsu· 2 shared G. Callahan· 2 shared G. Howe· 2 shared G. M. Alushin· 2 shared G. M. Quanrud· 2 shared J. C. Genereux· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

A. Baker

Mutual co-authors in cluster

Author profile →

14 papers

Recent·Most cited

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors

X. Lu, H. Hu, L. Mei, X. Wang, L. Xiong, Y. Zhu, S. Liu, W. Zhao, S. Mengnisa, L. Li, X. Lin, J. Liu, X. Wang, Z. Duan, W. Lu, , Y. Xu

This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.

bioRxiv · May 8, 2024 · PreprintBiochemistry

An Efficient and Safe Trans-complementation System for MPXV Mimicking Authentic Viral Infection

J. Liu, L. Zhu, L. Mei, Y. Liu, Y. Qu, Y. Yuan, F. Zhang, Y. Cao, Y. Zhu, W. Tai, J. Ma, M. Zheng, X. Shi, Y. Liu, G. Cheng

This paper develops a safe trans-complementation system for MPXV that mimics authentic infection, enabling research in lower biosafety labs without live virus.

bioRxiv · Dec 29, 2023 · PreprintMicrobiology

Transmembrane Stem Factor Nanodiscs Enhanced Revascularization in a Hind Limb Ischemia Model in Diabetic, Hyperlipidemic Rabbits

E. Takematsu, M. Massidda, G. Howe, J. Goldman, P. Felli, L. Mei, G. Callahan, A. Sligar, R. Smalling, A. Baker

This study tests tmSCF nanodiscs in a diabetic, hyperlipidemic rabbit model of hindlimb ischemia and finds improved vascularity without inflammation.

bioRxiv · Mar 20, 2023Bioengineering

Syndecan-4 Proteoliposomes Enhance Revascularization in a Rabbit Hind Limb Ischemia Model of Peripheral Ischemia

A. Sligar, G. Howe, J. Goldman, P. Felli, A. Gomez-Hernandez, E. Takematsu, A. Veith, S. Desai, W. Riley, R. Singeetham, L. Mei, G. Callahan, D. Ashirov, R. Smalling, A. Baker

This study shows that syndecan-4 proteoliposomes enhance blood vessel growth in a rabbit hind limb ischemia model when combined with growth factors.

bioRxiv · Sep 21, 2022Bioengineering

Factors Affecting Protein Recovery During Hsp40 Affinity Profiling

M. R. Montoya, G. M. Quanrud, L. Mei, J. L. Montano, C. Hong, J. C. Genereux

This study evaluates methods to improve Hsp40 affinity profiling for identifying stress-induced misfolded proteins, finding DNAJB8H31Q remains the most effective recognition element under stress.

bioRxiv · Mar 31, 2022Biochemistry

Structural mechanism for bi-directional actin crosslinking by T-plastin

L. Mei, M. J. Reynolds, D. Garbett, R. Gong, T. Meyer, G. M. Alushin

Cryo-EM, biochemical, and cellular studies reveal how the crosslinking protein T-plastin bridges actin filaments in two opposing orientations.

bioRxiv · Dec 7, 2021Biophysics

Hsp40 Affinity to Identify Proteins Destabilized by Cellular Toxicant Exposure

G. M. Quanrud, M. R. Montoya, L. Mei, M. R. Awad, J. C. Genereux

This study uses Hsp40 affinity to identify proteins destabilized by toxicant exposure and validates findings with a proteolysis assay.

bioRxiv · Sep 22, 2021Biochemistry

Detecting Phytophthora cinnamomi associated with dieback disease on Carya cathayensis using loop-mediated isothermal amplification

X. Tong, J. Wu, L. Mei, Y. Wang

The paper detects Phytophthora cinnamomi in Carya cathayensis using loop-mediated isothermal amplification and confirms its association with dieback disease.

bioRxiv · Sep 13, 2021Plant Biology

Mechanical Tension in Syndecan-1 is Regulated by Extracellular Mechanical Cues and Fluidic Shear Stress

V. Le, L. Mei, P. L. Voyvodic, C. Zhao, D. J. Busch, J. C. Stachowiak, A. B. Baker

This study investigates how syndecan-1 mechanical tension responds to substrate stiffness and fluidic shear stress in endothelial cells.

bioRxiv · May 9, 2020Bioengineering

Molecular mechanism for direct actin force-sensing by α-catenin

L. Mei, S. Espinosa de los Reyes, M. J. Reynolds, S. Liu, G. M. Alushin

This study shows that force on F-actin enhances E-catenin binding but not vinculin, revealing a modular mechanism for force-sensing by α-catenin.

bioRxiv · Feb 18, 2020Biophysics

Critical role for Slam/SAP signaling in the thymic developmental programming of IL-17- and IFN-γ-producing γδ T cells

O. Dienz, V. L. DeVault, S. C. Musial, S. K. Mistri, L. Mei, A. Baraev, J. A. Dragon, D. Krementsov, A. Veillette, J. E. Boyson

This study shows that SLAM/SAP signaling is critical for thymic development of IL-17 and IFN-γ-producing γδ T cells, with subset-specific dependencies.

bioRxiv · Oct 11, 2019Immunology

Novel pipeline of high-frequency neoantigens heathy donor-based validation in breast cancer

Q. li, H. ying, L. duan, L. geng, L. mei, A. ting, L. li, C. le, L. bo

The paper develops a computational pipeline to identify high-frequency neoantigens in breast cancer and validates their immunogenicity using healthy donor blood samples.

bioRxiv · Apr 4, 2019 · PreprintCancer Biology

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

L. J. Fulcher, Z. He, L. Mei, T. Macartney, N. Wood, A. R. Prescott, A. Whigham, J. Varghese, R. Gourlay, G. Ball, R. G. Clarke, D. G. Campbell, C. A. Maxwell, G. P. Sapkota

This study identifies FAM83D as a scaffold that recruits CK1α to the mitotic spindle, ensuring proper spindle positioning and timely cell division.

bioRxiv · Nov 27, 2018Cell Biology

SlARF10, an auxin response factor, is required for chlorophyll and sugar accumulation during tomato fruit development

L. Mei, Y. Yuan, M. Wu, Z. Gong, Q. Zhang, F. Yang, Q. Zhang, Y. Luo, X. Xu, W. Zhang, M. Miao, Z. Li, W. Deng

This study shows SlARF10 regulates chlorophyll and sugar accumulation in tomato fruits by controlling starch synthesis and photosynthesis.

bioRxiv · Jan 24, 2018Plant Biology