R. O. Dror

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

The paper determines the cryo-EM structure of active GPR161 bound to Gs, revealing sterol binding and its role in ciliary cAMP signaling, while showing that sterol binding is not essential for Hedgehog pathway suppression.

CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism

The paper reports cryoEM structures of human CLC-2 chloride channels, revealing a ball-and-chain gating mechanism involving an N-terminal hairpin peptide.

Structural basis for ion selectivity in potassium-selective channelrhodopsins

The paper determines the cryo-EM structures of two K+-selective channelrhodopsins, revealing a unique mechanism for K+ selectivity distinct from canonical K+ channels.

Structural insights into distinct signaling profiles of the μOR activated by diverse agonists

This study compares the structural and signaling differences between two μOR agonists, lofentanil and mitragynine pseudoindoxyl, revealing how their distinct binding modes lead to different G protein and β-arrestin activation profiles.

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

The paper presents the cryo-EM structure of ChRmine, revealing unique architectural features and provides insights into its conduction mechanism and potential for optogenetic applications.

Selective G protein signaling driven by Substance P-Neurokinin Receptor structural dynamics

This study investigates how different agonists of the NK1R receptor influence G-protein signaling through structural dynamics and extracellular loop interactions.

Leveraging non-structural data to predict structures of protein-ligand complexes

This paper presents a statistical framework combining physics-based and ligand-based methods to predict protein-ligand complex structures, improving pose prediction accuracy for drug targets.

Structural basis for sigma-1 receptor ligand recognition

This study presents crystal structures and MD simulations of the sigma-1 receptor bound to ligands, revealing agonist-induced structural changes and a multistep binding mechanism.