C. Zhong

Mechanisms mediating arylidene-indolinones induced degradation: thoughts on "Discovery of a Drug-like, Natural Product-Inspired, DCAF11 Ligand Chemotype"

The paper discusses discrepancies in conclusions about arylidene-indolinones' mechanism of action, suggesting possible explanations for conflicting findings on their role as DCAF11 ligands and autophagy-tethering compounds.

Mammalian Cell Models of the Distal Convoluted Tubule: A Systematic Review of Cell Lines, Culture Condition and Gene Expression

This review summarizes human, murine, and canine DCT cell models, their culture conditions, and gene expression, highlighting methodological inconsistencies and gaps in reporting.

A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

Seasonal Variation in Bacterial Community Structures of Mangrove Sediments

This study examines seasonal variations in mangrove sediment bacterial communities and identifies factors influencing their assembly mechanisms.

SunTag-PE: a modular prime editing system enables versatile and efficient genome editing

The paper introduces a modular prime editing system called SunTag-PE that improves delivery efficiency without compromising editing efficiency.

Microbial dysbiosis and metabolic disorders promote rheumatoid arthritis across successive stages: a multi-omics cohort study

This study identifies stage-specific microbial and metabolic changes in RA progression using multi-omics data from a cohort of patients.

Combinatorial mRNA vaccination enhances protection against SARS-CoV-2 delta variant

This study shows that combining mRNA vaccines targeting the SARS-CoV-2 spike and nucleoprotein proteins enhances protection against the delta variant in animal models.

The Genetic Basis of phage susceptibility, cross-resistance and host-range in Salmonella

This study identifies 301 host factors in Salmonella involved in phage resistance, reveals cross-resistance mechanisms between RpoS and RpoN, and shows additional constraints define phage host range.

The supramolecular organization of SARS-CoV and SARS-CoV-2 virions revealed by coarse-grained models of intact virus envelopes

This study constructs coarse-grained models of SARS-CoV and SARS-CoV-2 envelopes using cryo-EM data and simulations to analyze their structural and dynamic differences.

A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated super-enhancers

This study shows YY1 forms phase-separated super-enhancers by compartmentalizing coactivators and enhancer elements, with a histidine cluster essential for this process.

Targeted Bacteriophage T4 Nanoparticles Reverse HIV-1 Latency in CD4+ Human T Cells

The paper shows that CD4-targeted bacteriophage T4 nanoparticles reactivate HIV-1 latency in CD4+ T-cells without global activation or cytokine storm.

In the absence of reproductive isolation - Extensive gene flow after speciation

The paper sequenced two mangrove species to show extensive gene flow after speciation, with many small introgression blocks and genomic islets contributing to speciation.

Methylation of KRAS at lysine 182 and 184 by SETD7 promotes KRAS degradation

This study shows that SETD7 methylates KRAS at lysine 182 and 184, promoting its degradation and suppressing RAS/MEK/ERK signaling, thereby acting as a tumor suppressor in NSCLC.

High-throughput mapping of the phage resistance landscape in E. coli

This study maps host genetic determinants of phage resistance in E. coli using high-throughput genetic screens, identifying both known and novel resistance factors across 14 phages.

The long non-coding RNA lnc-HLX-2-7 is oncogenic in group 3 medulloblastomas

This study identifies lnc-HLX-2-7 as an oncogenic lncRNA in group 3 medulloblastomas, showing it promotes tumor growth and is regulated by MYC and JQ1.

In situ measurement of intracellular thermal conductivity using heater-thermometer hybrid diamond nanosensor

The paper measures intracellular thermal conductivity in HeLa cells using a hybrid diamond nanosensor, finding a mean value of 0.11 Wm-1K-1 with 40% variation.

A novel microRNA-based strategy to expand the differentiation potency of stem cells

This study shows that transient exposure to miR-203 enhances the differentiation capacity of murine and human PSCs by reversing DNA methylation.

Hsa_circ_0001947 suppresses acute myeloid leukemia progression by sponging hsa-miR-329-5p and regulating CREBRF expression

This study identifies hsa_circ_0001947 as a tumor suppressor in AML that inhibits cell proliferation and drug resistance by sponging hsa-miR-329-5p and regulating CREBRF expression.

3D cell culture stimulates the secretion of in vivo like extracellular vesicles

This study compares 2D and 3D cell culture-derived extracellular vesicles, finding that 3D EVs more closely resemble in vivo circulating EVs in small RNA profiles.

CRISPR/Cas9-mediated integration of large transgene into pig potential safe harbor

This study develops an efficient CRISPR/Cas9 method for integrating a large transgene cassette into the CEP112 locus in pigs, achieving successful expression of microbial enzymes in salivary glands.

Identification of the bacterial biosynthetic gene clusters of the oral microbiome illuminates the unexplored social language of bacteria during health and disease

This study identifies 4,915 bacterial biosynthetic gene clusters in the oral microbiome and finds differential representation of BGCs in health versus disease states like dental caries and periodontitis.

Nitric oxide synthase-mediated early nitric oxide-burst alleviates drought-induced oxidative damage in ammonium supplied-rice roots

This study shows that an early nitric oxide burst mediated by nitric oxide synthase in ammonium-supplied rice roots reduces drought-induced oxidative damage by enhancing antioxidant defenses.

Speciation with gene flow via cycles of isolation and migration: Insights from multiple mangrove taxa

The paper investigates speciation mechanisms in mangroves, finding that cycles of isolation and gene flow (MIM) drive speciation between oceanic regions, challenging the traditional model of strict allopatry.

Generation of a novel growth-enhanced and reduced environmental impact transgenic pig strain

This study generates transgenic pigs expressing microbial enzymes to enhance feed digestion and reduce nutrient emissions, showing improved growth and lower environmental impact.