M. N. Hall

This study identifies ALK signaling's role in enhancing DNA damage response in neuroblastoma, showing that combined ATR/ALK inhibition leads to sustained tumor response and differentiation.

This study shows that loss of adipose mTORC2 leads to increased hepatic lipogenesis and hypertriglyceridemia, but simultaneous inhibition in both tissues causes severe insulin resistance.

The paper shows elevated arginine levels in liver tumors drive metabolic reprogramming and tumor growth through feedback loops involving ASNS and arginase 1.

The paper identifies adipose mTORC2's role in sensory neuron arborization in white adipose tissue and links it to systemic insulin resistance.

This study identifies differentially regulated pathways and candidate driver genes in hepatocellular carcinomas through proteogenomic analysis across clinical stages and etiologies.

The paper shows that intestinal inflammation correlates with loss of LHPP and increased histidine phosphorylation in IECs, but LHPP loss alone does not cause inflammation.

This study presents a 3.2 Å resolution cryo-EM structure of human mTORC2, revealing structural features and regulatory mechanisms.

The paper shows that loss of Hexokinase 2 in adipose tissue due to high fat diet leads to hyperglycemia through systemic glucose homeostasis disruption.

The paper identifies essential genes for mTOR-dependent cancer growth that are not essential for bcr-abl transformed cells, suggesting distinct therapeutic targets.