K. Tharp

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

The microenvironment dictates glycocalyx construction and immune surveillance

This study shows that the physical properties of the microenvironment influence glycocalyx composition and immune surveillance in vitro using physiologically relevant models.

Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.

This study shows that uptake of tumor-derived microparticles by macrophages in the early metastatic lung leads to metabolic reprogramming and altered function.

Myeloid mechano-metabolic programming restricts anti-tumor immunity

This study shows that fibrotic tumor microenvironments impair anti-tumor immunity through myeloid cell-driven metabolic changes that hinder CD8+ T cell function.