M. Rudolph

The metabolic benefits of thermogenic stimulation are preserved in aging

This study shows that chronic beta3-AR stimulation improves metabolic function in aged mice by enhancing thermogenesis in brown adipose tissue and lipid turnover in white adipose tissue.

Structure of a human monoclonal antibody in complex with Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

This study determines the structure of a human monoclonal antibody in complex with OspC from Borreliella burgdorferi, revealing its epitope and interaction mechanism.

Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model

This study investigates MLKL's non-necroptotic roles in diet-induced obesity and liver disease using a HFHFrHC mouse model, finding dose-dependent effects on inflammation and metabolic parameters.

A genetic screen identifies a role for oprF in Pseudomonas aeruginosa biofilm stimulation by subinhibitory antibiotics

This paper identifies OprF and SigX as key factors in sub-MIC antibiotic-induced biofilm formation in Pseudomonas aeruginosa, linking periplasmic redox changes to c-di-GMP signaling.

Live imaging of Yersinia translocon formation and immune recognition in host cells

This study uses live imaging to track the formation, dynamics, and degradation of Yersinia T3SS translocons and their recognition by the immune system in host cells.

Visualization of bacterial type 3 secretion system components down to the molecular level by MINFLUX nanoscopy

The paper uses MINFLUX nanoscopy to visualize T3SS components at high resolution, revealing structural details of bacterial virulence factors.

Yersinia remodels epigenetic histone modifications in human macrophages

This study shows Yersinia enterocolitica modulates histone modifications in human macrophages to alter gene expression related to immune response and metabolism.

Thiostrepton hijacks pyoverdine receptors to inhibit growth of Pseudomonas aeruginosa

This paper identifies thiostrepton's activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii under iron-limited conditions by exploiting pyoverdine receptors.