Author

M. Subramanian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 2 Immunology· 2 Biophysics· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3

Frequent Co-Authors

A. U. KABIR· 3 shared K. CHOI· 3 shared K. KRCHMA· 3 shared A. Miaskowski· 2 shared J. Dobson· 2 shared J. WU· 2 shared M. KIM· 2 shared A. Aggarwal· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCancer Biology

A. U. KABIR

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Zbtb46 coordinates angiogenesis and immunity to control tumor outcome

A. U. KABIR, M. SUBRAMANIAN, M. KIM, J. WU, K. KRCHMA, X. WANG, C. M. HALABI, H. PAN, S. A. WICKLINE, D. H. FREMONT, K. CHOI

This study identifies Zbtb46 as a regulator that coordinates angiogenesis and immunity in tumors, with its downregulation promoting a pro-tumor microenvironment and its restoration improving tumor outcomes.

bioRxiv · Mar 2, 2023 · PreprintCancer Biology

Interleukin-1α and Leukemia Inhibitory Factor Promote Extramedullary Hematopoiesis

D. Barisas, M. Kim, M. Subramanian, A. U. Kabir, K. Krchma, J. Wu, B. Zinselmeyer, C. Stewart, K. Choi

This study identifies IL-1 and LIF as factors promoting EMH by activating splenic niche cells and inducing an inflammatory gene signature in HSPCs.

bioRxiv · Jul 7, 2022 · PreprintImmunology

Robust and durable prophylactic protection conferred by RNA interference in preclinical models of SARS-CoV-2

Y. I. Anglero-Rodriguez, F. A. Lempp, J. McIninch, M. K. Schlegel, C. R. Brown, D. J. Foster, A. B. Castoreno, T. Nguyen, M. Subramanian, M. Montiel-Ruiz, H. Kaiser, A. Sahakyan, R. Spreafico, S. S. Morskaya, J. D. Barry, , V. Jadhav

This study identifies two siRNA combinations that provide robust prophylactic protection against SARS-CoV-2 in hamsters by reducing viral load and preventing lung pathology.

bioRxiv · Mar 20, 2022 · PreprintPharmacology & Toxicology

Conserved angio-immune subtypes of the cancer microenvironment predict response to immune checkpoint blockade therapy

M. Subramanian, A. U. Kabir, D. A. G. Barisas, K. Krchma, K. Choi

The paper identifies three conserved angio-immune subtypes in cancer microenvironments and shows that high immune activity with low angiogenesis correlates with better response to immune checkpoint blockade therapy.

bioRxiv · Dec 23, 2021Cancer Biology

Microenvironmental correlates of immune checkpoint inhibitor response in human melanoma brain metastases revealed by T cell receptor and single-cell RNA sequencing

C. A. Alvarez-Breckenridge, S. C. Markson, J. H. Stocking, N. Nayyar, M. Lastrapes, M. R. Strickland, A. E. Kim, M. de Sauvage, A. Dahal, J. M. Larson, J. L. Mora, A. W. Navia, B. M. Kuter, C. M. Gill, M. S. Bertalan, , Bra

bioRxiv · Aug 25, 2021Cancer Biology

Eosinophils restrict diesel exhaust particles induced cell proliferation of lung epithelial A549 cells, vial interleukin-13 mediated mechanisms: implications for tissue remodelling and fibrosis

R. Niranjan, M. Subramanian, D. Panneer, S. K. Ojha

This study shows that diesel exhaust particles induce eosinophil proliferation and interleukin-13 release, which restricts lung epithelial cell proliferation and may contribute to tissue remodeling and fibrosis.

bioRxiv · Mar 30, 2021Cell Biology

Hypercholesterolemia Impairs Clearance of Extracellular DNA and Promotes Inflammation and Atherosclerotic Plaque Progression

U. K. Dhawan, P. Bhattacharya, S. Narayanan, V. Manickam, A. Aggarwal, M. Subramanian

This study shows hypercholesterolemia impairs DNA clearance by reducing DNase activity, leading to inflammation and atherosclerosis progression in mice and humans.

bioRxiv · Oct 5, 2020 · PreprintImmunology

DNA-Encircled Lipid Bilayers

K. Iric, M. Subramanian, J. Oertel, N. P. Agarwal, M. Matthies, X. Periole, T. P. Sakmar, T. Huber, K. Fahmy, T.-L. Schmidt

This paper introduces DNA-encircled bilayers (DEBs) as a novel membrane-mimetic system for studying lipid phases and membrane proteins with precise control over size and functionalization.

bioRxiv · Jun 25, 2018Biophysics

Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death

M. Subramanian, A. Miaskowski, S. I. Jenkins, J. Lim, J. Dobson

This study investigates the use of magnetic field gradients to manipulate magnetic nanoparticles and induce cancer cell death in vitro.

bioRxiv · May 22, 2018Bioengineering

Practical bioinstrumentation developments for AC magnetic field-mediated magnetic nanoparticle heating applications.

M. Subramanian, A. Miaskowski, A. K. Mahapatro, O. Hovorka, J. Dobson

The paper develops an instrument for AC magnetic field-mediated magnetic nanoparticle heating applications, demonstrating its use in temperature monitoring, drug release analysis, and thermal imaging.

bioRxiv · May 22, 2018Bioengineering