Author

M. Schaich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

B. Van Houten· 3 shared D. Sobota· 2 shared J. Cama· 2 shared U. F. Keyser· 2 shared B. B. Chen· 1 shared B. D. Freudenthal· 1 shared B. Wang· 1 shared B. Zhu· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

B. Van Houten

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Author profile →

5 papers

Recent·Most cited

SON-dependent nuclear speckle rejuvenation alleviates proteinopathies

W. Dion, Y. Tao, M. Chambers, S. Zhao, R. K. Arbuckle, M. Sun, S. Kubra, M. Schaich, Y. Nie, M. Ye, I. Jamal, M. B. Larsen, D. Camarco, E. Ickes, H. Wang, , B. Zhu

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

bioRxiv · Apr 18, 2024Cell Biology

The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA.

S. R. Hengel, K. Oppenheimer, C. Smith, M. Schaich, H. L. Rein, J. Martino, K. Darrah, O. C. Ezekwenna, K. R. Burton, B. Van Houten, M. Spies, K. A. Bernstein

This study shows the Shu complex enhances RAD51 activity by stabilizing filaments and promoting RPA diffusion on ssDNA, with implications for cancer therapy.

bioRxiv · Feb 14, 2024Biochemistry

Single-molecule analysis of purified proteins and nuclear extracts: insights from 8-oxoguanine glycosylase 1

M. Schaich, T. M. Weaver, V. Roginskaya, B. D. Freudenthal, B. Van Houten

This study compares single-molecule DNA binding dynamics of purified OGG1 and nuclear extracts using SMADNE, revealing differences in undamaged DNA binding and increased binding lifetime for a catalytically dead variant in nuclear extracts.

bioRxiv · Nov 1, 2023Biochemistry

Biophysical characterization reveals the similarities of liposomes produced using microfluidics and electroformation

M. Schaich, D. Sobota, H. Sleath, J. Cama, U. F. Keyser

The paper compares biophysical properties of GUVs produced by microfluidics and electroformation, finding similar lateral diffusion coefficients.

bioRxiv · Nov 28, 2019Biophysics

An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes

M. Schaich, J. Cama, K. Al Nahas, D. Sobota, K. Jahnke, S. Deshpande, C. Dekker, U. F. Keyser

The paper develops a microfluidic platform to measure drug permeability across biomimetic liposome membranes, demonstrating improved control and yield compared to existing methods.

bioRxiv · Jan 17, 2019Biophysics