M. Sen

Jagged-1+ Skin Tregs Modulate the Innate Immune Response to Wound Healing

This study shows that Jag1-expressing skin Tregs delay wound closure by reducing neutrophil recruitment but do not affect other immune cell populations or hair regeneration.

Requirement of a Wnt5A-Microbiota Axis in the Maintenance of Gut B Cell Repertoire and Protection from Infection

This study shows that Wnt5A and gut microbiota interact to maintain B cell repertoire and protect against infection, with Wnt5A heterozygous mice showing increased susceptibility to Salmonella.

Full-length αIIbβ3 CryoEM structure reveals intact integrin initiate-activation intrinsic architecture

This paper presents the cryoEM structure of full-length αIIbβ3 integrin, revealing its activation states and providing insights into its role in platelet function and potential therapeutic targeting.

Therapeutic potential of rWnt5A in curbing Leishmania donovani infection

This study shows that rWnt5A reduces L. donovani infection in macrophages and mice by increasing ROS and IFN-γ/IL-10 ratio, and improving immune cell function and splenic organization.

Chorography and conformational dynamism of the Soluble Human Fibrinogen in solution

This study presents a conformationally dynamic model of soluble human fibrinogen in solution using biophysical methods, revealing internal flexibility and a complex conformational landscape.

Wnt5A Signaling Regulates Gut Bacterial Survival and T cell Homeostasis

This study shows that Wnt5A signaling promotes survival of gut commensals and affects T cell balance, highlighting its role in maintaining gut bacterial diversity and immune homeostasis.

Wnt5A supports antigen cross-presentation and CD8 T cell activation.

This study shows Wnt5A supports antigen cross-presentation and CD8 T cell activation by regulating actin and proteasome dynamics in dendritic cells.

Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis

This study shows that Wnt5A signaling reduces susceptibility to visceral leishmaniasis by limiting infection progression and preserving immune cell function in mice.

Pharmacological inhibition of the VCP/proteasome axis rescues photoreceptor degeneration in RHOP23H rat retinal explants

The paper shows that inhibiting VCP/proteasome activity rescues photoreceptor degeneration in RHOP23H rat retinal explants.

Self-assembled nanoparticles enable delivery of VCP inhibitor, resulting in enhanced photoreceptor protection in retinal explants

The paper develops nanoformulations of a VCP inhibitor to improve its solubility and delivery, showing enhanced photoreceptor protection in a retinal degeneration model.

Host Response to Bacterial Pathogens and Non-Pathogens is Determined by Wnt5A Mediated Actin Organization

The paper shows Wnt5A signaling influences macrophage killing of pathogenic E. coli K1 by promoting actin assembly, while non-pathogenic E. coli strains resist this effect.

Complement receptor 3 forms a compact high affinity complex with iC3b

This study shows that CR3 forms a high-affinity complex with iC3b, which enhances phagocytosis and informs therapeutic development.