K. Ray

TREM2 Orchestrates Myeloid Cell Programming and Immune Dysregulation in Pulmonary Hypertension

This study identifies TREM2 as a regulator of myeloid cell function and immune dysregulation in pulmonary hypertension, showing its role in disease progression and potential as a therapeutic target.

Insulin signaling accelerates the anterograde movement of Rab4 vesicles in axons through Klp98A/KIF16B recruitment via Vps34-PI3Kinase

This study shows insulin signaling increases Rab4 vesicle transport in axons by recruiting Klp98A via Vps34-PI3Kinase activation in Drosophila.

The structure of NAD+ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations.

The paper reports the crystal structure of Acinetobacter baumannii TIR domain and its NAD+ hydrolase activity, showing conformational changes and kinetic effects upon substrate binding.

Chorography and conformational dynamism of the Soluble Human Fibrinogen in solution

This study presents a conformationally dynamic model of soluble human fibrinogen in solution using biophysical methods, revealing internal flexibility and a complex conformational landscape.

The interplay of active and passive mechanisms in slow axonal transport

The paper models slow axonal transport of ChAT in Drosophila neurons, showing that changes in diffusive fraction during development dominate bleach recovery, and active transport alone cannot explain the data.

DNA Self-Assembled Plasmonic Nanodiamonds for Biological Sensing

This study develops plasmon-enhanced nanodiamonds (PEN) for biological imaging by using DNA self-assembly to improve brightness and temporal resolution of NV centers.

Heterotrimeric kinesin-2 motor subunit, KLP68D, localises Drosophila odour receptor coreceptor in the distal domain of the olfactory cilia

This paper shows that the Drosophila odor receptor coreceptor (Orco) enters olfactory cilia in two stages post-eclosion and is localized to the distal ciliary domain by the kinesin-2 motor complex.

Nanoscale indentation of plasma membrane establishes a contractile actomyosin scaffold through selective activation of the Amphiphysin-Rho1-Dia/DAAM and Rok pathway

The paper shows that nanoscale stretching of the plasma membrane recruits Amphiphysin and Rho1, leading to actomyosin scaffold formation that clamps spermatid heads.

Atypical septate junctions maintain the somatic enclosure around maturing spermatids and prevent premature sperm release in Drosophila testis.

The paper shows that septate junctions maintain the somatic enclosure around maturing spermatids in Drosophila testis, preventing premature sperm release and ensuring proper fertility.