A. Turner

Enzymatic access to the rare ΔUA (1->4) Glc 3, 6, N-sulfated heparin disaccharide, implications for heparin quality control

This study characterizes a Bacteroides eggerthii lyase that efficiently cleaves heparin to release a rare anticoagulant disaccharide, offering improved methods for quality control.

Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10

This study defines the substrate recognition mechanism of Doa10 using structural and functional analyses in yeast, revealing a lateral tunnel and fence-like domains that facilitate substrate access.

Haptenic adducts of beta-lactam antibiotics elicit antibody responses with narrow clonality and specificity

This study investigates how penicillin G forms immunogenic adducts on proteins and elicits specific antibody responses in mice, revealing clonal dominance and limited cross-reactivity with other beta-lactam antibiotics.

Daytime broadcast spawning in cryptic Pocillopora species at Mo'orea, French Polynesia

The paper documents the first scientific reports of broadcast spawning for six cryptic Pocillopora species at Moorea, showing species-specific lunar and diel spawning timing.

Factors Influencing the Detection of Antibacterial Resistant Escherichia coli in Faecal Samples from Individual Cattle

This study examines factors affecting the detection of antibiotic-resistant E. coli in cattle faecal samples, finding that sampling methods and storage duration are more influential than on-farm antibiotic use.

A thermodynamic model for interpreting tryptophan excitation-energy-dependent fluorescence spectra provides insight into protein conformational sampling and stability

The paper develops a thermodynamic model to quantify the relationship between the tryptophan red edge excitation shift effect and protein flexibility, using examples across multiple scales and protein types.

Monoclonal antibody stability can be usefully monitored using the excitation-energy-dependent fluorescence edge-shift

This paper demonstrates that quantifying the fluorescence red edge excitation shift (REES) can sensitively monitor monoclonal antibody stability across timeframes and concentrations.