Author

M.-C. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

A. Vancea· 1 shared B. Reed· 1 shared C.-C. Lin· 1 shared C.-H. Lin· 1 shared C.-J. Wu· 1 shared C.-Y. Hsu· 1 shared E. Israelsson· 1 shared G. Y. T. Tan· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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1 shared paperScientific Communication & Education

A. Vancea

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Author profile →

5 papers

Recent·Most cited

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity

C.-H. Lin, C.-J. Wu, S. Cho, R. Patkar, L.-L. Lin, M.-C. Chen, E. Israelsson, J. Betts, M. Niedzielska, S. A. Patel, H. G. Duong, R. R. Gerner, C.-Y. Hsu, M. Catley, R. A. Maciewicz, , L.-F. Lu

This study identifies intestinal regulatory T cells producing IL-27 to specifically regulate Th17 immunity in the gut, revealing a novel mechanism for tissue-specific immune control.

bioRxiv · Feb 20, 2023Immunology

Structural analyses of the plant PRT6-UBR box in the Cys-Arg/N-degron pathway and insights into the plant submergence response

L. Kim, C.-C. Lin, T.-J. Lin, Y.-C. Cao, M.-C. Chen, M.-Y. Chou, W.-H. Lin, M. Kim, J.-L. Wu, M.-C. Shih, H. K. Song, M.-C. Ho

This study determines the structure of PRT6-UBR box in rice and Arabidopsis and identifies conserved motifs critical for Cys-Arg/N-degron recognition, showing that modifying these motifs improves submergence tolerance in Arabidopsis.

bioRxiv · Aug 19, 2022 · PreprintBiochemistry

Acinar-to-ductal metaplasia in the pancreas requires a glycolytic switch and functional mitochondria

T. Neuss, N. Wirges, M.-C. Chen, S. Usluer, R. Oellinger, S. Lier, M. Dudek, T. Madl, M. Jastroch, K. Steiger, W. Schmitz, H. Einwaechter, R. M. Schmid

This study identifies a glycolytic switch and functional mitochondria as essential for acinar-to-ductal metaplasia, a key step in pancreatic carcinogenesis.

bioRxiv · Jun 27, 2022 · PreprintCancer Biology

An Experimental Test of the Effects of Redacting Grant Applicant Identifiers on Peer Review Outcomes

R. Nakamura, L. S. Mann, M. D. Lindner, J. Braithwaite, M.-C. Chen, A. Vancea, N. Byrnes, V. Durrant, B. Reed

This study tests if redacting grant applicant identities reduces bias in peer review, finding that redaction reduces but does not eliminate racial score differences.

bioRxiv · Jun 25, 2021Scientific Communication & Education

Interplay between Desmoglein2 and hypoxia controls metastasis in breast cancer

P.-H. Chang, M.-C. Chen, Y.-P. Tsai, G. Y. T. Tan, P.-H. Hsu, Y.-M. Jeng, Y.-F. Tsai, M.-H. Yang, W. W. Hwang-Verslues

This study identifies DSG2 as a key factor in breast cancer metastasis, showing that hypoxia dynamically regulates DSG2 to control tumor cell dissemination and colonization.

bioRxiv · Nov 9, 2020Cancer Biology