Author

N. CHOUDHRY

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

D. Yang· 3 shared G. Lv· 3 shared Q. Shi· 3 shared T. Zhang· 3 shared C. Yang· 2 shared H. Li· 2 shared H. Liu· 2 shared J. Kalashova· 2 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

D. Yang

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pharmacokinetics, Tissue Distribution, and Formulation Study of a Small-molecule Inhibitor of MKLP2, LG157

N. CHOUDHRY, J. Li, T. Zhang, J. Chenyu, X. Zhou, Q. Shi, G. Lv, D. Yang

This study evaluates the drug developability of LG157, a MKLP2 inhibitor, by assessing its pharmacokinetics, tissue distribution, and formulation using SEDDS.

bioRxiv · Dec 25, 2023 · PreprintCancer Biology

MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality

D. Yang, J. Kalashova, C. Yang, Y. Long, H. Li, S. Zhang, T. Zhang, D. Yu, X. Liu, G. Lv, N. Choudhry, H. Liu, Q. Shi

This study shows that LXY18 selectively kills MYC-overexpressing cancer cells by inducing mitotic arrest, offering a new approach to target MYC-driven tumors.

bioRxiv · Nov 7, 2023 · PreprintCancer Biology

An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment

D. YANG, J. Li, T. Zhang, Q. Shi, G. Lv, X. Zhou, N. CHOUDHRY, J. Kalashova, C. Yang, H. Li, Y. Long, B. Sakthivel, N. Nimishetti, H. Liu, T. D. Allen, J. Zhang

This paper identifies LXY18, a 4-phenoxy-quinoline compound that blocks AURKB relocalization, showing potent antimitotic activity and oral bioavailability.

bioRxiv · Jan 29, 2023 · PreprintCancer Biology