P. Han

Generative Modelling of Oncogene-carrying Extrachromosomal Circular DNA Biogenesis and Dynamics in Cells

The paper develops a method to generate oncogene-carrying ecDNAs in human cells and studies their expression and stability under different conditions.

MicroRNA-27a-5p downregulates the expression of proinflammatory cytokines in lipopolysaccharide-stimulated human dental pulp cells via NF-κB signaling pathway

This study shows miR-27a-5p reduces proinflammatory cytokines in LPS-stimulated hDPCs by inhibiting NF-κB signaling through targeting TAB1.

Chemical genetic interaction linking eIF5A hypusination and mitochondrial integrity

This study investigates the effects of eIF5A hypusination inhibition on mitochondrial function and identifies MPV17L2 as a key regulator involved in mitochondrial integrity.

Proliferation history and transcription factor levels drive direct conversion

This study identifies proliferation history and transcription factor levels as key drivers of direct conversion of fibroblasts to motor neurons using a synthetic biology approach.

Unveiling unique microbial nitrogen cycling and novel nitrification drivers in coastal Antarctica

This study identifies unique microbial nitrogen cycling mechanisms in coastal Antarctica, highlighting the role of comammox Nitrospira in nitrification.

TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis

This study shows TERT promotes thyroid cancer dedifferentiation and progression by enhancing ribosome biogenesis, and inhibiting rRNA synthesis can reverse this process.

De novo design of site-specific protein interactions with learned surface fingerprints

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

Reduced sera neutralization to Omicron SARS-CoV-2 by bothinactivated and protein subunit vaccines and the convalescents

The paper tests neutralization activity of sera from convalescents and vaccine recipients against Omicron, finding that vaccines maintain better neutralization than convalescents.

Comparative proteomic analysis of vancomycin-sensitive and vancomycin-intermediate resistant S. aureus

This study compares proteomic profiles of vancomycin-intermediate resistant S. aureus strains to identify differentially expressed proteins associated with vancomycin resistance.

Neutralization of recombinant RBD-subunit vaccine ZF2001-elicited antisera to SARS-CoV-2 variants including Delta

This study evaluates the neutralizing activity of ZF2001 vaccine-elicited antisera against SARS-CoV-2 variants, finding that E484K/Q mutations reduce neutralization and that extended intervals between doses improve variant resilience.

Identification of glutamine synthetase as a novel contryphan-Bt binding protein by his-tag pull down

The paper identifies glutamine synthetase as a novel contryphan-Bt binding protein using His-tag pull down assays and confirms the interaction with microscale thermophoresis.

Comparative analysis of clonal evolution among patients with right-sided colon cancer, left-sided colon cancer and rectal cancer

This study compares clonal evolution across right-sided colon cancer, left-sided colon cancer, and rectal cancer patients, finding differences in evolutionary patterns and identifying polyclonal origins of lymph node and extranodal tumor deposits.

Global analysis of epigenetic heterogeneity identifies divergent drivers of esophageal squamous cell carcinoma

The paper identifies epigenetic drivers of esophageal squamous cell carcinoma through multi-omics analysis, revealing hypomethylation patterns and non-canonical WNT signaling activation.

Projected changes of alpine grassland carbon dynamics in response to climate change and elevated CO2 concentrations under Representative Concentration Pathways (RCP) scenarios

The paper uses a biogeochemistry model to project changes in alpine grassland carbon dynamics under climate change and elevated CO2, finding a net carbon sink with decreasing sequestration capacity and precipitation's growing role.

Integrated multi-omics analysis to study the effects of simulated weightlessness on rhesus macaques (Macaca mulatta)

This study uses multi-omics analysis to examine the effects of simulated weightlessness on rhesus macaques, identifying molecular changes in blood, muscle, brain regions, and fecal samples.