Author

N. Ilott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

F. Powrie· 3 shared C. Pearson· 2 shared E. E. Thornton· 2 shared M. Friedrich· 2 shared Y. Gu· 2 shared A. Bertocchi· 1 shared A. Janney· 1 shared B. A. Steere· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

F. Powrie

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3 papers

Recent·Most cited

MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses

C. Heuberger, A. Janney, N. Ilott, A. Bertocchi, S. Pott, Y. Gu, M. Pohin, M. Friedrich, E. Mann, C. Pearson, F. Powrie, J. Pott, E. E. Thornton, K. J. Maloy

This study shows that intestinal epithelial cells expressing MHC II modulate CD4 T cell responses during intestinal inflammation, dampening pro-inflammatory effector Th cells.

bioRxiv · Jan 23, 2023Immunology

A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

C.-P. Hackstein, D. Costigan, L. Drexhage, C. Pearson, S. Bullers, N. Ilott, H. D. Akther, Y. Gu, M. E. B. FitzPatrick, O. J. Harrison, L. C. Garner, E. H. Mann, S. Pandey, M. Friedrich, N. M. Provine, , E. E. Thornton

The paper identifies a conserved population of MHC-II restricted, innate-like T cells in the gut of humans and mice that react to commensals and are implicated in colitis.

bioRxiv · Sep 26, 2022 · PreprintImmunology

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23

D. Aschenbrenner, M. Quaranta, S. Banerjee, N. Ilott, J. Jansen, B. A. Steere, Y.-H. Chen, S. Ho, K. Cox, Oxford IBD Cohort Investigators, C. V. Arancibia-Carcamo, M. Coles, E. Gaffney, S. Travis, L. A. Denson, , H. H. Uhlig

The paper identifies IL-10 and IL-1 cytokine networks that regulate IL-23 production in monocytes, distinguishing homeostatic from hyper-inflammatory IL-23 production in inflammatory bowel disease.

bioRxiv · Jan 31, 2020 · PreprintImmunology