Selective Activation of TASK-3-containing K+ Channels Reveals Their Therapeutic Potentials in Analgesia
P. Liao, Y. Qiu, Y. Mo, J. Fu, Z. Song, L. Huang, S. Bai, Y. Wang, J. J. Zhu, F. Tian, Z. Chen, N. Pan, E. Y. Sun, L. Yang, X. Lan, , H. Yang
The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.
bioRxiv · Jun 28, 2019 · PreprintPharmacology & Toxicology