Author

N. Phan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

D. Nicastro· 3 shared A. N. Hata· 2 shared G. Fu· 2 shared L. Zhao· 2 shared A. Abbasi· 1 shared A. Lagisetty· 1 shared A. Langenbucher· 1 shared A. Maoz· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCell Biology

D. Nicastro

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction

K. Vaccaro, J. Allen, T. W. Whitfield, A. Maoz, S. Reeves, J. Velarde, D. Yang, N. Phan, G. W. Bell, A. N. Hata, K. Weiskopf

The paper identifies targeted therapies that enhance lung cancer vulnerability to macrophage attack when combined with anti-CD47 antibodies, showing synergy across multiple genetic mutations.

bioRxiv · Mar 3, 2023Cancer Biology

Three-dimensional cilia structures from animals' closest unicellular relatives, the Choanoflagellates

J. M. Pinskey, A. Lagisetty, L. Gui, N. Phan, E. Reetz, G. Fu, D. Nicastro

This study uses cryo-electron tomography to analyze cilia structures in Choanoflagellates, revealing features more similar to metazoan cilia than to those of other unicellular organisms.

bioRxiv · Feb 24, 2022 · PreprintCell Biology

Structural organization of the C1b projection within the ciliary central apparatus

K. Cai, Y. Zhao, L. Zhao, N. Phan, G. Witman, D. Nicastro

The paper identifies and characterizes the subunit organization of the C1b projection in the central apparatus of cilia, revealing its role in regulating dynein activity and ciliary beating.

bioRxiv · Jun 16, 2021Cell Biology

APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancer

H. Isozaki, A. Abbasi, N. Nikpour, A. Langenbucher, W. Su, M. Stanzione, H. Frisco-Cabanos, F. M. Siddiqui, N. Phan, P. Jalili, S. Oh, D. Timonina, S. Bilton, M. Gomez-Caraballo, H. L. Archibald, , A. N. Hata

This study shows that APOBEC3A mutagenesis driven by targeted therapies promotes drug resistance in non-small cell lung cancer.

bioRxiv · Jan 20, 2021Cancer Biology

Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus

G. Fu, L. Zhao, E. Dymek, Y. Hou, K. Song, N. Phan, Z. Shang, E. F. Smith, G. B. Witman, D. Nicastro

The paper identifies and localizes subunits of the ciliary central apparatus using cryo-electron tomography and genetic approaches in Chlamydomonas.

bioRxiv · Sep 18, 2019Cell Biology

A simple high-throughput approach identifies actionable drug responses in patient-derived tumor organoids

N. Phan, J. J. Hong, B. Tofig, M. Mapua, D. Elashoff, N. A. Moatamed, J. Huang, S. Memarzadeh, R. Damoiseaux, A. Soragni

This paper introduces a high-throughput method for drug screening using tumor organoids and identifies effective drugs for ovarian cancer within a week of surgery.

bioRxiv · Aug 13, 2018Cancer Biology