G. Fu

Multi-omics map revealed PPARalpha activation protecting against myocardial ischemia-reperfusion injury by maintaining cardiac metabolic homeostasis

The paper identifies PPARalpha activation as protective against myocardial ischemia-reperfusion injury by maintaining cardiac metabolic homeostasis, using multi-omics data from rat hearts.

The ciliary MBO2 complex targets assembly of inner arm dynein b and reveals additional doublet microtubule asymmetries

The paper identifies the MBO2 complex as a regulator of inner arm dynein b assembly in cilia and reveals its structural organization on doublet microtubules.

Cryo-electron tomography of eel sperm flagella reveals a molecular "minimum system" for motile cilia

This study uses cryo-electron tomography to analyze the structure of eel sperm flagella, revealing a minimal system with retained remnants of regulatory complexes and unique structural features.

RGA1 alleviates low-light-repressed pollen tube growth by improving the metabolism and allocation of sugars and energy

This study shows RGA1 improves pollen tube growth under low-light by enhancing sugar and energy metabolism in rice pistils.

Mouse primary T cell phosphotyrosine proteomics enabled by BOOST

The paper applies the BOOST method to perform phosphotyrosine proteomics on mouse primary T cells, demonstrating improved quantitation depth and accuracy by disabling the ΦSDM parameter in Orbitrap instruments.

Three-dimensional cilia structures from animals' closest unicellular relatives, the Choanoflagellates

This study uses cryo-electron tomography to analyze cilia structures in Choanoflagellates, revealing features more similar to metazoan cilia than to those of other unicellular organisms.

RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer

The paper shows that loss of RNASEH2B makes prostate cancer cells sensitive to PARP inhibitors, but co-deletion with RB1 reduces this sensitivity through BRCA2 upregulation, and ATR inhibition can restore sensitivity.

Circadian Control of Heparan Sulfate Levels Times Phagocytosis of Amyloid Beta Aggregates

This study shows that circadian rhythms control heparan sulfate levels, which regulate phagocytosis of amyloid-beta aggregates in a mouse model of Alzheimer's disease.

Compensating complete loss of signal recognition particle during co-translational protein targeting by the translation speed and accuracy

The paper identifies a suppressor mutation that compensates for SRP loss by slowing translation and reducing fidelity, allowing correct protein targeting in E. coli.

Development of A Novel Highly Selective TLR8 Agonist for Cancer Immunotherapy

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

G1/S transcription factors assemble in discrete clusters that increase in number as cells grow

The paper uses PALM to show SBF/MBF transcription factors form clusters in yeast cells, with cluster number increasing as cells grow.

Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus

The paper identifies and localizes subunits of the ciliary central apparatus using cryo-electron tomography and genetic approaches in Chlamydomonas.

FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia

This study identifies FAP57/WDR65 as a docking factor that targets specific inner dynein arms to the 96 nm axonemal repeat and connects to regulatory hubs in cilia.

BTLA and PD-1 employ distinct phosphatases to differentially repress T cell signaling

This study identifies that BTLA and PD-1 use distinct phosphatases to differentially repress T cell signaling, highlighting mechanistic differences between two co-inhibitory receptors.

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

This study identifies FAK activity as a driver of platinum resistance in ovarian cancer by sustaining CSC survival and DNA repair, showing that FAK inhibitors combined with platinum can overcome resistance.

The differential distribution of bacteria between cancerous and noncancerous ovarian tissues in situ

This study compares bacterial composition and functional differences between cancerous and noncancerous ovarian tissues using 16S rRNA sequencing and metagenomic predictions.