W. Su

Exenatide administration time determines the effects on blood pressure dipping in db/db mice via modulation of food intake and sympathetic activity

This study shows that exenatide administration time affects blood pressure dipping in db/db mice by altering food intake and sympathetic activity, with efficacy dependent on food availability and circadian timing.

PFKP regulates AXL-MET oncogenic and metabolic pathways in lung cancer

This study shows PFKP promotes lung cancer progression by interacting with the AXL-MET pathway, beyond its metabolic role in glycolysis.

A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

This study identifies mutations in the P protein of Avian paramyxovirus type 1 that drive host shift from chickens to pigeons through enhanced degradation of LSm14A.

Sequence-based prediction of the solubility of peptides containing non-natural amino acids

The paper presents CamSol-PTM, a computational method to predict solubility of peptides with non-natural amino acids, validated through experimental testing of 30 variants.

Retrotransposons hijack alt-EJ DNA repair process for mobilization and eccDNA biogenesis

This study shows retrotransposons use the alt-EJ DNA repair pathway to generate eccDNA and achieve mobilization.

Boreal Forest Height Mapping using Sentinel-1 Time Series and improved LSTM model

This paper develops an improved LSTM model for predicting boreal forest height using Sentinel-1 time series, achieving better accuracy than existing methods.

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

Senescent Preosteoclast Secretome Promotes Metabolic Syndrome Associated Osteoarthritis through Cyclooxygenase 2

This study identifies a senescent preosteoclast secretome-COX2/PGE2 axis as a driver of metabolic syndrome-associated osteoarthritis, with selective COX2 inhibitors showing therapeutic potential.

piggyBac-Mediated Genomic Integration of Linear dsDNA-Based Library for Deep Mutational Scanning in Mammalian Cells

This paper develops two new strategies for constructing large variant DMS libraries in mammalian cells using piggyBac-mediated genomic integration and in-vitro ligation.

Assessment of AI-based Protein Structure Prediction for the NLRP3 Target

This study evaluates AI-based protein structure prediction for NLRP3, showing that AI models can generate reliable structures useful for small-molecule drug discovery.

Effects of dual deletion of glnR and mtrA on expression of nitrogen metabolism genes in Streptomyces venezuelae

This study examines how the dual deletion of glnR and mtrA affects nitrogen metabolism gene expression in Streptomyces venezuelae, revealing GlnR's decisive role and MtrA's GlnR-dependent regulation.

Using hypertemporal Sentinel-1 data to predict forest growing stock volume

This study uses Sentinel-1 SAR data to predict forest growing stock volume, showing improved accuracy with more images and specific seasonal image combinations.

Lung adenocarcinoma cell-derived exosomal miR-328 promote osteoclastogenesis by targeting Nrp2

This study shows that exosomal miR-328 from lung adenocarcinoma cells promotes osteoclastogenesis by targeting Nrp2 and suggests its inhibitors as a potential treatment for bone metastasis.

APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancer

This study shows that APOBEC3A mutagenesis driven by targeted therapies promotes drug resistance in non-small cell lung cancer.

Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome

The paper investigates how defective interfering genomes affect wild-type poliovirus replication using a mathematical model and experimental data, finding that DI replication and encapsidation are key factors in determining viral competition outcomes.

Sequencing of clinical samples reveals that adaptation keeps establishing during H7N9 virus infection in humans

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

Authentication of In Situ Measurements for Thoracic Aortic Aneurysms in Mice

The paper develops an in situ method using OCT injection to accurately measure thoracic aortic aneurysms in mice without causing damage.

De novo design of ACE2 protein decoys to neutralize SARS-CoV-2

The paper designs de novo ACE2 protein decoys to neutralize SARS-CoV-2 by blocking viral entry, showing high affinity and potent in vitro inhibition.

Active Time-Restricted Feeding Protects the Blood Pressure Circadian Rhythm in Diabetic Mice

This study shows that time-restricted feeding prevents nondipping blood pressure in diabetic mice by restoring circadian rhythms through mechanisms involving BMAL1 and sympathetic vascular tone.

Construction of High Content Nanobody Library in Mammalian Cells by Linear-double-stranded DNA Based Strategies

The paper develops two methods to construct high-content nanobody libraries in mammalian cells using linear-double-stranded DNA strategies, generating over a million unique sequences.

Compartmentalization of enhanced biomolecular interactions for high-throughput drug screening in test tubes

This paper introduces a high-throughput drug screening method called CEBIT that detects biomolecular interactions and enzyme inhibitors by using phase-separated compartments.

Influenza H3 and H1 hemagglutinins have different genetic barriers for resistance to broadly neutralizing stem antibodies

The paper evaluates genetic barriers to resistance against broadly neutralizing antibodies targeting the stem region of influenza H3 and H1 hemagglutinins, finding H3 has lower resistance barriers.

Generation of highly diverse peptide library by linear-double-stranded DNA based AND gate genetic circuit in mammalian cells

The paper develops a method to generate diverse peptide libraries in mammalian cells using an ldsDNA-based AND gate genetic circuit, demonstrating sequence and length diversity through HTS and identifying an MDM2-interacting peptide.