P. A. Iglesias

This study uses optogenetics to show that RasGAPs regulate cell polarity by enhancing actomyosin contractility at the back and F-actin polymerization at the front.

This study identifies a dynamic partitioning mechanism that explains asymmetric membrane protein distribution during signaling events.

The paper shows nanotopography is sensed directly by cytoskeletal networks, with implications for texture sensing and guidance cues in microenvironments.

This study shows that surface charge regulation on the plasma membrane integrates signaling networks to control cell polarity and migration through dynamic changes in phospholipid composition.

This paper uses 3D stochastic simulations to model chemoattractant-mediated excitability in cells, showing that noise-driven excitable systems underlie pseudopod formation and migration, with implications for understanding directed cell movement.

This paper develops barcoding proteins to enable highly multiplexed imaging of biosensors in live cells by computationally unmixing signals from different biosensors.

This study identifies Adenine Nucleotide Translocase (ANT) as a protective factor against cigarette smoke in lung cells, showing its role in mitochondrial metabolism, airway hydration, and ciliary function in COPD.