P. Dhami

Clonal sharing of CD8+ T-cells links skin and joint inflammation in psoriatic arthritis

The paper identifies shared CD8+ T-cell clones between skin and joint in psoriatic arthritis, suggesting clonal migration and coordinated inflammation.

Single-cell analysis identifies distinct macrophage phenotypes associated with pro-disease and pro-resolving functions in the endometriotic niche

The paper identifies distinct macrophage phenotypes in endometriosis using single-cell analysis, linking them to disease-promoting and resolving functions.

Unanticipated interacting features of human gut-associated lymphoid tissues link microbiota, intestinal immunity and autoimmunity

The paper identifies DN2 B cells in human GALT that interact with DC expressing DNASE1L3 and C1Q, linking microbiota, immunity, and autoimmunity.

Mapping the Spatial Dynamics of the Human Oral Mucosa in Chronic Inflammatory Disease

The paper maps spatial dynamics in human oral mucosa using single-cell and spatial transcriptomics to identify immune programs and pathogenic fibroblasts in chronic inflammation.

Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood

The paper identifies two distinct subsets of human marginal zone B cells through global analysis of lymphoid tissues and blood, revealing differences in their biology and distribution.

Human marginal zone B cell development from early T2 progenitors

The paper identifies an IgMhi developmental trajectory in human B cell maturation that connects T2 progenitors to marginal zone B cells and links its disruption to severe SLE.

Macrophages can inhibit and enhance endometriosis depending on their origin

This study shows that macrophages in endometriosis lesions can either promote or suppress disease depending on their origin, with eutopic endometrial macrophages being pro-endometriosis and recruited monocyte-derived macrophages being anti-endometriosis.