M. Mack

Bacterial vaginosis-driven changes in cervicovaginal immunity that expand the immunological hypothesis for increased HIV susceptibility

This study investigates how bacterial vaginosis alters cervicovaginal immunity, identifying immune cell changes that may contribute to increased HIV susceptibility.

RAG suppresses group 2 innate lymphoid cells

This study shows that RAG suppresses group 2 innate lymphoid cells (ILC2s), affecting their cytokine production and contributing to inflammation in atopic dermatitis.

Mutation of the P. falciparum flavokinase confers resistance to roseoflavin and 8-aminoriboflavin

This study identifies a mutation in the P. falciparum flavokinase gene that confers resistance to roseoflavin and 8-aminoriboflavin by reducing substrate binding affinity.

Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis

This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.

IgG4 serum levels are not elevated in cases of Post-COVID syndrome

The paper compares IgG subtypes in Post-COVID patients and controls, finding no elevation in IgG4 but reduced IgG2, suggesting potential role of IgG2 in Post-COVID syndrome.

Synthetic STING agonists elicit powerful vaccine adjuvancy providing robust central memory and anti-tumour effects

This study shows synthetic STING agonists enhance CD8+ T-cell responses, memory formation, and anti-tumour effects in mice, with implications for immunotherapy and vaccines.

Monocyte-derived peritoneal macrophages protect C57BL/6 mice against surgery-induced adhesions

This study shows that monocyte-derived peritoneal macrophages reduce surgery-induced adhesions in C57BL/6 mice, while BALB/c mice show increased adhesions with reduced monocyte influx.

Roseoflavin, a natural riboflavin analogue, possesses in vitro and in vivo antiplasmodial activity

This study identifies roseoflavin as an antimalarial compound that inhibits Plasmodium parasite growth by targeting riboflavin metabolism and cofactor utilization, showing in vitro and in vivo efficacy.

Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions and monocytes for optimal therapeutic protection

This study shows that neutralizing antibodies against SARS-CoV-2 need intact Fc functions and monocytes for optimal therapeutic protection in animal models.

Cold Exposure Protects from Neuroinflammation Through Immunologic Reprogramming

The paper shows cold exposure reduces neuroinflammation by altering monocyte function and T cell priming in mouse models of autoimmune encephalomyelitis.

Macrophages can inhibit and enhance endometriosis depending on their origin

This study shows that macrophages in endometriosis lesions can either promote or suppress disease depending on their origin, with eutopic endometrial macrophages being pro-endometriosis and recruited monocyte-derived macrophages being anti-endometriosis.