P. Brown

Conserved cold tolerance of Rhagoletis species from different host fruits, elevations in Colorado, USA

This study examines cold tolerance in two Rhagoletis species from different host fruits and elevations, finding conserved supercooling points and survival at low temperatures.

Large-scale phenotypic and genomic characterization of Listeria monocytogenes susceptibility to quaternary ammonium compounds

This study characterizes QAC susceptibility in 1,671 L. monocytogenes isolates, identifies genetic markers linked to tolerance, and examines global prevalence across 37,897 genomes.

Resolution doubling in light-sheet microscopy via oblique plane structured illumination

This paper demonstrates isotropic resolution doubling in light-sheet microscopy using oblique plane structured illumination, achieving sub-150nm lateral resolution with reduced phototoxicity and faster volumetric imaging.

Activation of ChvG-ChvI regulon by cell wall stress confers resistance to β-lactam antibiotics and initiates surface spreading in Agrobacterium tumefaciens

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

Degradation of mixed-linkage (1,3;1,4)-β-D-glucan in maize is mediated by the CAL1 licheninase

The paper identifies CAL1 as a licheninase responsible for degrading mixed-linkage (1,3;1,4)-β-D-glucan in maize, showing its role in regulating MLG content and saccharification efficiency.

Machine learning enabled phenotyping for GWAS and TWAS of WUE traits in 869 field-grown sorghum accessions

This study uses machine learning and phenotyping to identify 394 genes associated with water use efficiency traits in sorghum through GWAS and TWAS of 869 field-grown accessions.

Morphometric and Molecular Discrimination of the sugarcane aphid, Melanaphis sacchari, (Zehntner, 1897) and the sorghum aphid Melanaphis sorghi (Theobald, 1904)

This study uses morphometric and molecular data to distinguish between two aphid species, finding that M. sorghi is the invasive genotype damaging sorghum in the US, Mexico, and the Caribbean since 2013.

Comparison of Rhesus and Cynomolgus macaques as an authentic model for COVID-19.

This study compares rhesus and cynomolgus macaques as models for mild to moderate COVID-19, showing similar viral replication, immune responses, and histopathology.

An Assistive Computer Vision Tool to Automatically Detect Changes in Fish Behavior In Response to Ambient Odor

This paper develops a computer vision tool to automate detection of zebrafish behavioral changes in response to ambient odor using deep learning with minimal expert supervision.

Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge

This study investigates the dose-dependent response of ferrets to SARS-CoV-2 infection, showing protection against re-challenge and mild clinical disease.

Physiological Artifacts and the Implications for Brain-Machine-Interface Design

This study models cardiac artifacts in brain-machine interfaces and finds that skull-mounted devices require less CMRR to suppress ECG artifacts compared to pectoral-mounted systems.

Genetic variation associated with PPO-inhibiting herbicide tolerance in sorghum

This study identifies genetic variants associated with tolerance to PPO-inhibiting herbicides in sorghum and suggests a metabolism-based resistance mechanism.

\"Ghost ponds\" - How to resurrect in-filled farmland ponds to assist aquatic biodiversity conservation in agricultural landscapes

This study demonstrates that resurrecting filled-in agricultural ponds (ghost ponds) can rapidly restore aquatic biodiversity, achieving comparable species diversity to newly restored ponds within a year.

Identification and Characterization of the First Fragment Hits for SETDB1 Tudor Domain

The paper identifies small molecule fragments that bind to the tudor domain of SETDB1 and describes their binding modes and biophysical properties.

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

This study identifies CYRI proteins as local inhibitors of Scar/WAVE-induced lamellipodia that bind to active Rac1, regulating protrusion size and complexity.