P. Murray

Longevity Bottlenecks

This paper surveys experts in longevity to identify key bottlenecks and solutions, finding that data sharing and regulatory clarity are critical for advancing aging research.

Near infrared conjugated polymer nanoparticles (CPN) for tracking cells using fluorescence and optoacoustic imaging

This study develops near-infrared conjugated polymer nanoparticles (CPNs) for cell tracking using fluorescence and optoacoustic imaging, showing they outperform indocyanine green (ICG) in some applications.

Intravenous administration of human umbilical cord mesenchymal stromal cells leads to an inflammatory response in the lung

The paper investigates the lung's inflammatory response to intravenous hUC-MSCs in mice, finding an initial pro-inflammatory phase followed by resolution.

Multicentre comparison of biological and functional properties of mesenchymal stromal cells from different sources cultivated using a harmonised manufacturing workflow

This study compares MSC characteristics across three tissue sources using harmonised culture conditions, finding reproducible results and source-specific functional differences.

Comparison between optical tissue clearing methods for detecting administered mesenchymal stromal cells in mouse lungs

This study compares optical tissue clearing methods to detect mesenchymal stromal cells in mouse lungs, finding that CUBIC enables direct imaging of fluorescently labeled MSCs and their interaction with host cells.

Computed tomography lacks sensitivity to image gold labelled mesenchymal stromal cells in vivo as evidenced by multispectral optoacoustic tomography.

The paper compares imaging modalities for tracking gold-labelled mesenchymal stromal cells in vivo, finding that CT lacks sensitivity compared to BLI and MSOT.

Age related defects in NK cell immunity revealed by deep immune profiling of pediatric cancer patients

The paper uses high dimensional single cell analysis to reveal age-related immune changes in NK and T-cells of pediatric cancer patients and age-matched healthy children.

Murine models of renal ischaemia reperfusion injury: An opportunity for refinement using non-invasive monitoring methods

This paper refines murine models of renal ischaemia reperfusion injury (R-IRI) using non-invasive monitoring methods to improve reproducibility and enable longitudinal tracking of kidney function.

In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells

This study compares the in vivo fate of free and encapsulated iron oxide nanoparticles after labeling stem cells, finding both formulations accumulate in liver and spleen and are not fully cleared after two weeks.

Development of an imaging toolbox to assess the therapeutic potential and biodistribution of macrophages in a mouse model of multiple organ dysfunction

The paper develops an imaging toolbox to assess macrophage therapy effects in a mouse model of multi-organ dysfunction, finding limited functional improvement but persistent macrophage biodistribution in kidneys and liver.

Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration

The paper uses non-invasive imaging to study how cell type, administration route, and immune status affect the fate and safety of administered human and murine cells in mice.

Magnetic resonance imaging for characterization of a chick embryo model of cancer cell metastases

This study uses MRI with contrast agents to detect metastatic neuroblastoma in a chick embryo model, showing its effectiveness compared to fluorescence methods.

Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes

This paper combines gold nanorods and reporter genes to track cells over time in mice, showing biodistribution and tumour growth.