J. Zuo

Monocytic fibrocyte-like cell enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity

The paper identifies fibrocyte-like cells as key drivers of nucleus pulposus fibrosis in disc degeneration, showing their role in myofibroblast formation and disease severity.

Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma

The paper uses spatial transcriptomics and scRNA-Seq to analyze fibroblast subtypes in pancreatic ductal adenocarcinoma, linking their transcriptomes to clinical outcomes and suggesting therapeutic targets.

S-nitrosylation of Aux/IAA protein represses auxin signaling

The paper shows that S-nitrosylation of IAA17 at Cys-70 inhibits its degradation and reduces auxin signaling, affecting plant development.

Immunological imprinting of humoral immunity to SARS-CoV-2 in children

This study examines immune responses to Omicron variants in children, finding weak initial antibody responses that improve with reinfection or vaccination, while cellular immunity remains robust across all groups.

Synthetic Nanobody-Functionalized Nanoparticles for Accelerated Development of Rapid, Accessible Detection of Viral Antigens

This paper introduces Nano2RED, a rapid, affordable diagnostic platform using nanobody-functionalized nanoparticles to detect viral antigens with high sensitivity and speed.

A single episode of CMV reactivation initiates long-term expansion and differentiation of the NK cell repertoire

Nitric oxide negatively regulates gibberellin signaling to coordinate growth and salt tolerance in Arabidopsis

This study shows that nitric oxide inhibits gibberellin signaling by S-nitrosylating RGA, balancing growth and salt tolerance in Arabidopsis under salinity stress.

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection

This study shows that SARS-CoV-2-specific T-cell immunity remains robust six months after infection, with response magnitude linked to initial infection severity.

A new method for distinguishing human and mouse cells in situ

This paper introduces a method using DAPI staining to distinguish human and mouse cells in situ, showing distinct nuclear structures in mouse cells.

Age related defects in NK cell immunity revealed by deep immune profiling of pediatric cancer patients

The paper uses high dimensional single cell analysis to reveal age-related immune changes in NK and T-cells of pediatric cancer patients and age-matched healthy children.

Sapphire-Supported Nanopores for Low-Noise DNA Sensing

This paper introduces sapphire-supported nanopore membranes with reduced capacitance and noise, improving DNA sensing accuracy and speed compared to silicon-supported nanopores.

TLR2 signaling pathway combats Streptococcus uberis infection by inducing production of mitochondrial reactive oxygen species

This study shows that TLR2 signaling reduces S. uberis infection severity by promoting mitochondrial reactive oxygen species production in mammary epithelial cells.

PROTEOME-WIDE ANALYSIS OF CD8+ T CELL RESPONSES TO EBV REVEALS DIFFERENCES BETWEEN PRIMARY AND PERSISTENT INFECTION

This study compares CD8+ T cell responses to EBV in primary infection and persistent carriage by analyzing reactivity against lytic cycle proteins.