R. Alvarez

IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function

The paper identifies IL-13-programmed airway tuft cells that produce PGE2, which enhances CFTR-dependent mucociliary function in allergic airways.

Enhancing Myocardial Repair with CardioClusters

This paper introduces CardioClusters, 3D microenvironments of cardiac interstitial cells that enhance myocardial repair by improving cell retention, function, and structural outcomes in a murine infarction model.

Deep metagenomics examines the oral microbiome during dental caries, revealing novel taxa and co-occurrences with host molecules

This study uses deep metagenomics to analyze the oral microbiome in children with and without dental caries, identifying novel taxa and host-microbe interactions.

Adaptation Within Embryonic and Neonatal Heart Environment Reveals Alternative Fates for Adult c-Kit+ Cardiac Interstitial Cells

This study investigates the adaptability of adult c-Kit+ cardiac interstitial cells (cCICs) when delivered to embryonic, fetal, and postnatal hearts, revealing their fibroblast-like fate and limited contribution to cardiogenesis.

The Autoimmune Susceptibility Gene, PTPN2, Restricts Expansion of a Novel Mouse Adherent-Invasive E. coli

This study shows PTPN2 deficiency in mice promotes expansion of a novel adherent-invasive E. coli that worsens colitis.

Identification of the bacterial biosynthetic gene clusters of the oral microbiome illuminates the unexplored social language of bacteria during health and disease

This study identifies 4,915 bacterial biosynthetic gene clusters in the oral microbiome and finds differential representation of BGCs in health versus disease states like dental caries and periodontitis.