Author

A. Ranganathan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Singhal· 3 shared M. Marothia· 3 shared S. Singh· 3 shared A. Chaurasiya· 2 shared A. K. Kahlon· 2 shared A. Khedkar· 2 shared M. Chatterji· 2 shared M. Gromiha· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMicrobiology

J. Singhal

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mapping Structural Drivers of Insulin and its Analogs at the IGF-1 Receptor Using Molecular Dynamics and Free Energy Calculations

A. Ranganathan, M. M. Sena, R. C, M. Gromiha, M. Chatterji, A. Khedkar

This study uses molecular dynamics and free energy calculations to predict insulin analog potency at IGF-1R and identify structural drivers of activity.

bioRxiv · Dec 2, 2023 · PreprintBiophysics

Host inducible-HSP70A1A is an irresistible drug target to combat SARS-CoV-2 infection and pathogenesis

P. Joshi, S. Garg, S. Mani, K. Jakhar, M. Marothia, R. Shoaib, S. Biswas, J. Singhal, A. Behl, A. K. Kahlon, M. Shevtsov, P. Garg, S. Singh, A. Ranganathan

This study shows that inhibiting host Hsp70 reduces SARS-CoV-2 infection more effectively than Remdesivir by blocking viral entry and autophagy.

bioRxiv · May 5, 2023 · PreprintMicrobiology

Identification of merozoite secreted repertoire and immuno-pharmacological inhibition of a novel host-parasite interaction to block malarial infection

N. Singh, A. Munjal, G. Kunari, S. Kaushik, A. K. Kahlon, S. Gupta, A. Chaurasiya, Z.-e.- Anam, M. k. Maurya, P. Srivastava, J. Singhal, M. Marothia, P. Joshi, R. Jain, D. A. B. Rex, , S. Singh

This study identifies the secretory repertoire of Plasmodium merozoites and discovers a peptide that disrupts a key host-parasite interaction, blocking malarial infection.

bioRxiv · Apr 15, 2023 · PreprintMicrobiology

Mapping Structural Drivers of Insulin Analogs Using Molecular Dynamics and Free Energy Calculations at Insulin Receptor

A. Ranganathan, M. M. M. Sena, R. Chandrasekaran, M. Chatterji, A. Khedkar, M. Gromiha

This study uses molecular dynamics and free energy calculations to analyze insulin-IR interactions and identify potency determinants in natural and synthetic insulin analogs.

bioRxiv · May 27, 2022 · PreprintBiophysics

Targeting the artemisinin resistant malaria by repositioning of the anti-Hepatitis C Virus drug Alisporivir

A. Chaurasiya, S. Garg, Z. e. Anam, G. Kumari, N. Joshi, J. Kumari, J. Singhal, N. Singh, S. Kaushik, A. Kaur, n. Dubey, P. Srivastava, M. Marothia, M. Kumar, G. Das, , A. Ranganathan

This study repositions Alisporivir, an anti-Hepatitis C drug, as a potential treatment for artemisinin-resistant malaria by targeting PfCyP-19B, which is overexpressed in resistant parasites.

bioRxiv · Jan 8, 2021 · PreprintMicrobiology