A. Wallace

Extracellular vesicles-based point-of-care testing for the diagnosis and monitoring of Alzheimer's disease

This paper presents an OECT-based sensor for rapid, sensitive detection of extracellular vesicles in Alzheimer's disease, showing improved sensitivity and reduced detection time.

Absolute Quantification of Microbiota in Shotgun Sequencing Using Host Cells or Spike-Ins

This paper introduces methods to calculate absolute microbial abundances in shotgun sequencing using spike-ins or host cells, showing consistent results with qPCR and manufacturer values.

Discovery of prevalent, clinically actionable tumor neoepitopes via integrated biochemical and cell-based platforms

The paper identifies 84 clinically relevant neoepitope-HLA pairs from 37 shared cancer neoantigens using a combination of biochemical assays and computational methods.

Fc-engineered antibodies leverage neutrophils to drive control of Mycobacterium tuberculosis

This study uses Fc-engineered antibodies to enhance Mtb control by leveraging neutrophils, showing restrictive Fc variants improve neutrophil survival and antimicrobial activity in a human whole blood model.

Origins and timing of emerging lesions in advanced renal cell carcinoma

This study uses multi-region sequencing to analyze the origins and timing of tumor lesions in advanced renal cell carcinoma, finding that metastases often emerge early and VTT forms later through inflammatory processes.

Indication-specific tumor evolution and its impact on neoantigen targeting and biomarkers for individualized cancer immunotherapies

The paper analyzes tumor evolution across cancer types to identify factors affecting neoantigen targeting in immunotherapy.

Oral administration of a single anti-CfaE nanobody provides broadly cross-protective immunity against major pathogenic Enterotoxigenic Escherichia coli strains

This study shows that oral administration of a single nanobody provides broad protection against multiple ETEC strains by targeting conserved epitopes.