Author

K. Perry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:ATAC-seq· 1 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Tindle· 2 shared E. Vidales· 2 shared P. Ghosh· 2 shared S. Taheri· 2 shared A. A. Robertson· 1 shared A. Adel· 1 shared A. Fonseca· 1 shared A. Ondersma· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

C. Tindle

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis

H. Peters, P. Potla, J. S. Rockel, T. Tockovska, C. Pastrello, I. Jurisica, K. D. Santos, S. Vohra, S. Lively, K. Perry, N. Looby, S. H. Li, V. Chandran, K. Hueniken, P. Kaur, , M. Kapoor

This study uses multi-omic approaches to analyze cellular and transcriptomic diversity in infrapatellar fat pad during knee osteoarthritis, identifying fibroblasts as key contributors to disease-related differences.

bioRxiv · Apr 4, 2024Cell Biology

Machine Learning Guided Differentiation Therapy Targets Cancer Stem Cells in Colorectal Cancers

S. Sinha, J. Alcantara, K. Perry, V. Castillo, A. Ondersma, S. Banerjee, E. McLaren, C. R. Espinoza, S. Taheri, E. Vidales, C. Tindle, A. Adel, S. Amirfakhri, J. R. Sawires, J. Yang, , P. Ghosh

This paper introduces a machine learning framework to identify and target transcriptomic vulnerabilities in colorectal cancer, demonstrating that differentiation therapy selectively eliminates cancer stem cells and reduces recurrence risk.

bioRxiv · Sep 13, 2023 · PreprintCancer Biology

A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics

C. Tindle, G. Katkar, A. Fonseca, S. Taheri, J. Lee, P. Maity, I. Sayed, S.-R. Ibeawuchi, E. Vidales, R. Pranadinata, M. Fuller, D. Stec, M. S. Anandachar, K. Perry, H. Lee, , P. Ghosh

This paper creates a biobank of patient-derived organoids to identify molecular subtypes of Crohn's disease and test subtype-specific therapies.

bioRxiv · Mar 11, 2023Immunology

Increased core body temperature exacerbates defective protein prenylation in mouse avatars of mevalonate kinase deficiency

M. A. Munoz, O. P. Skinner, E. Masle-Farquhar, J. Jurczyluk, Y. Xiao, E. K. Fletcher, E. Kristianto, M. P. Hodson, S. I. O'Donoghue, S. Kaur, R. Brink, D. Zahra, E. K. Deenick, K. Perry, A. A. Robertson, , M. J. Rogers

This study shows that increased body temperature worsens protein prenylation defects in mouse models of mevalonate kinase deficiency, suggesting temperature as a trigger for inflammation.

bioRxiv · Feb 28, 2022 · PreprintPhysiology

ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes

F. Shi, J. M. Mendrola, J. B. Sheetz, N. Wu, A. Sommer, K. F. Speer, J. N. Noordermeer, Z.-Y. Kan, K. Perry, S. W. Englander, S. E. Stayrook, L. G. Fradkin, M. A. Lemmon

The paper presents crystal structures of Drosophila ROR and RYK orthologs, revealing distinct WNT-recognition mechanisms through their extracellular domains.

bioRxiv · Apr 29, 2021Biochemistry