W. Lei

Immunogenicity of autologous and allogeneic human primary cholangiocyte organoids

The immune response to human primary cholangiocyte organoids is ameliorated by donor-recipient HLA matching.

Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia

This study identifies aquaporins in endothelial cells that regulate microvascular diameter in hyperglycemia, suggesting they are potential targets for diabetes-related vascular therapy.

The synergistic effects of plants and nitrogen on microbial hitchhiking

The paper investigates how plants and nitrogen fertilizer influence microbial hitchhiking, finding that their synergy affects soil microbiome composition and function depending on nitrogen levels.

Endogenous glucocorticoids are required for normal macrophage activation and gastric Helicobacter pylori immunity

This study shows that glucocorticoids are necessary for proper macrophage activation and immune response to Helicobacter pylori in the stomach.

An Endogenous Aryl Hydrocarbon Receptor Ligand Induces Preeclampsia-like Phenotypes: Transcriptome, Phosphoproteome, and Cell Functions

This study shows that an endogenous AhR ligand induces PE-like phenotypes by altering transcriptome, phosphoproteome, and vascular functions in pregnant rats and HUVECs.

Efficient inhibition of fusion inhibitor HY3000 peptide to SARS-CoV-2 emerging EG.5, EG.5.1 and BA.2.86 variants

This study evaluates the inhibitory activity of the HY3000 peptide against emerging SARS-CoV-2 variants EG.5, EG.5.1, and BA.2.86, finding it retains potent antiviral effects.

Culture substrate stiffness impacts human myoblast contractility-dependent proliferation and nuclear envelope wrinkling

This study shows that fibronectin promotes stronger stiffness-dependent responses in human myoblasts compared to laminin and collagen, with softer substrates increasing nuclear wrinkling linked to proliferation.

Identification of age and ethnicity specific gene expression biomarkers for immune aging

This study identifies age and ethnicity-specific gene expression biomarkers for immune aging using transcriptomic data from peripheral blood mononuclear cells.

Unravelling processes between phenotypic plasticity and population dynamics in migratory birds

This study investigates how the loss of staging habitats affects migration strategies and population dynamics in migratory birds through phenotypic plasticity.

Identification of SARS-CoV-2 induced pathways reveal drug repurposing strategies

The paper identifies 200 approved drugs that target SARS-CoV-2-induced pathways, with 40 in clinical trials, and classifies them into viral replication and immune response mechanisms.

Potential mechanisms of action of celastrol against rheumatoid arthritis: transcriptomic and proteomic analysis

This study identifies potential mechanisms of celastrol's anti-inflammatory effects in rheumatoid arthritis by analyzing transcriptomic and proteomic changes in fibroblast-like synoviocytes.

Strategy for Efficient Importing of NAD Analogs

The paper describes a strategy to develop an efficient importing system for NAD analogs to enhance their application in studying NAD-mediated signaling pathways.