ImmunologybioRxivPreprint
Macrophages sense ECM mechanics and growth factor availability through cytoskeletal remodeling to regulate their tissue repair program
DOI 10.1101/2023.06.28.545586
Author
R. Medzhitov
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Biology Disciplines
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2019-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 18 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- ImmunologybioRxivPreprint
Immune sensing of food allergens promotes aversive behaviour
E. B. Florsheim, N. D. Bachtel, J. Cullen…·R. Medzhitov
This study shows that immune sensing of food allergens drives antigen-specific behavioural aversion in mice, involving IgE, mast cells, and leukotrienes, and extends to lipopolysaccharide-induced inflammation.
DOI 10.1101/2023.01.19.524823 - ImmunologybioRxiv
Microenvironmental sensing by fibroblasts controls macrophage population size
X. Zhou, R. A. Franklin, M. Adler…·R. Medzhitov
This study shows fibroblasts sense space and regulate macrophage numbers via growth factor production.
DOI 10.1073/pnas.2205360119 - ImmunologyJournal of Experimental MedicinePeer-reviewed
Hepatic FGF21 mediates tissue tolerance during bacterial inflammation by preserving cardiac function
S. C. Huen, A. Wang, K. Feola…·R. Medzhitov
This study shows that hepatic FGF21 promotes survival during bacterial inflammation by preserving cardiac function, and its signaling via beta-Klotho is required for this protective effect.
DOI 10.1084/jem.20202151 - BiochemistrybioRxiv
Adiponectin and related C1q/TNF-related proteins bind selectively to anionic phospholipids and sphingolipids
J. J. Ye, X. Bian, J. Lim, R. Medzhitov
This study shows adiponectin and related CTRP proteins bind to anionic phospholipids and sphingolipids, suggesting they function as lipid-binding opsonins or carriers.
DOI 10.1073/pnas.1922270117