A. Hu

Strong cascading impacts of micropollutants on planktonic food web in urban river

This study examines how micropollutants affect planktonic food webs in urban rivers, finding stronger impacts in more urbanized areas with algal-mediated cascading effects.

Lipid-anchored Proteasomes Control Membrane Protein Homeostasis

This study identifies N-myristoylation of Rpt2 as a mechanism for proteasome-membrane interaction, showing its role in membrane protein homeostasis and its impact on cellular processes and tumor growth.

Characterization of Pro-Fibrotic Signaling Pathways using Human Hepatic Organoids

This study uses human hepatic organoids to identify pro-fibrotic signaling pathways and potential therapies for liver fibrosis.

Mass-immigration shapes the antibiotic resistome of wastewater treatment plants

The paper monitors antibiotic resistance genes in wastewater treatment plants and finds that mass-immigration of bacteria and ARGs from upstream units shapes ARG communities, with stochastic processes dominating their assembly.

Extracellular disintegration of viral proteins as an innovative strategy for developing broad-spectrum antivirals against coronavirus

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

Matrix-seq: An adjustable-resolution spatial transcriptomics via microfluidic matrix-based barcoding.

Matrix-seq provides a microfluidic barcoding method for adjustable-resolution spatial transcriptomics, reducing technical barriers and enabling application in multiple biological fields.

Hydrological dynamics drive the transition of antibiotic resistance genes between particle-attached and free-living lifestyles in a deep freshwater reservoir

This study examines how seasonal hydrological changes affect the transition of antibiotic resistance genes between particle-attached and free-living lifestyles in a deep freshwater reservoir.

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

Active Translation Control of CD4 T Cell Activation by Regulatory T Cells

This study shows regulatory T cells suppress CD4 T cell activation by inhibiting translation of mRNAs encoding protein synthesis machinery, highlighting translational control in immune tolerance.

Repeated introduction of micropollutants enhances microbial succession despite stable degradation patterns

The paper examines how repeated micropollutant exposure affects microbial community succession and degradation patterns in freshwater systems.

Quantifying microbial associations of dissolved organic matter under global change

The paper develops a framework to quantify DOM-microbe associations under global change, finding that molecular traits and nutrient enrichment influence these interactions differently in subarctic and subtropical climates.

The cardiac STAT3 intercalated disc specific expression in tail suspension rat

This study examines right ventricle remodeling in tail-suspended rats under microgravity simulation, finding STAT3 accumulation and gap junction remodeling without significant hypertrophy.

Dextran sulfate sodium salt corrupted colonic crypts declined the smooth muscle tension in mouse large intestine

This study shows that DSS-induced colitis in mice damages colonic crypts, leading to reduced smooth muscle tension and impaired myogenic contractions.

Heat Shock Protein 27 Immune Complex Upregulates LDLR Expression Thereby Reducing Plasma Cholesterol and Atherogenesis

The paper shows that HSP27 immune complexes increase LDLR expression, lowering plasma cholesterol and atherogenesis in ApoE-/- mice.