Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein using mRNA Display
A. Norman, C. Franck, M. Christie, P. Hawkins, K. Patel, A. Ashhurst, A. Aggarwal, J. K. Low, R. Siddiquee, C. Ashley, M. Steain, J. A. Triccas, S. G. Turville, J. Mackay, T. Passioura, R. J. Payne
The paper identifies cyclic peptide ligands to the SARS-CoV-2 spike protein RBD using mRNA display, finding six high-affinity molecules with nanomolar dissociation constants.
ACS Central Science · Jun 23, 2021Peer-reviewedBiochemistry