R. V. Pappu

LASSI simulates phase transitions of multivalent proteins using a lattice model, generating insights into condensate formation and design.

This study shows that spontaneous interactions between proteins and RNA can form multi-layered condensates with distinct material properties and specific amino acid and RNA sequence dependencies.

The paper measures NDC80 binding to microtubules in living cells and finds it is regulated by centromere tension and phosphorylation of Hec1.

The paper investigates the structure of Httex1 with expanded polyQ and finds that its tadpole-like conformation increases interactions in cells, potentially contributing to neurotoxicity.

This study shows that disordered linkers in multivalent proteins control the relationship between phase separation and gelation through their length and sequence features.