R. Yee

Metagenomic Next-Generation Sequencing of Rectal Swabs for the Surveillance of Antimicrobial Resistant Organisms on the Illumina Miseq and Oxford MinION Platforms

This study evaluates mNGS on Illumina MiSeq and Nanopore MinION platforms for detecting MDRO in rectal swabs, showing concordance with culture results and highlighting advantages of both short and long-read approaches.

Ranking of Major Classes of Antibiotics for Activity against Stationary Phase Pseudomonas aeruginosa and Identification of Clinafloxacin + Cefuroxime + Gentamicin Drug Combination that Eradicates Persistent P. aeruginosa Infection in a Murine Cystic Fibrosis Model

A Drug Combination Approach Targeting Both Growing Bacteria and Dormant Persisters Eradicate Persistent Staphylococcus aureus Biofilm Infection

This study demonstrates that combining antibiotics targeting both growing bacteria and persisters eradicates S. aureus biofilm infections more effectively than current treatments.

Identification of Genes Regulating Cell Death in Staphylococcus aureus

This study identifies genes regulating cell death in Staphylococcus aureus through a genome-wide screen, revealing both death-resistant and death-sensitive mutants with implications for virulence and antibiotic persistence.

Biofilm/Persister/Stationary Phase Bacteria Cause More Severe Disease Than Log Phase Bacteria II Infection with Persister Forms of Staphylococcus aureus Causes a Chronic Persistent Skin Infection with More Severe Lesion that Takes Longer to Heal and is not Eradicated by the Current Recommended Treatment in Mice

Biofilm/Persister/Stationary Phase Bacteria Cause More Severe Disease Than Log Phase Bacteria IBiofilm Borrelia burgdorferi Not Only Display More Tolerance to Lyme Antibiotics But Also Cause More Severe Pathology In a Mouse Arthritis Model: Implications for Understanding Persistence, PTLDS and Treatment Failure

This study shows that biofilm and persister forms of Borrelia burgdorferi cause more severe arthritis in mice than log phase forms, suggesting their role in persistent Lyme disease.