Author

S. Fletcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Tait-Burkard· 2 shared A. Alzetani· 1 shared A. B. Lawrence· 1 shared A. Baker· 1 shared A. Bhaskar· 1 shared A. Daniels· 1 shared A. Fabre· 1 shared A. Fox· 1 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersImmunology

C. Tait-Burkard

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Stem cell-derived macrophages as a new platform for studying host-pathogen interactions in livestock

S. Meek, T. Watson, L. Eory, G. McFarlane, F. J. Wynne, S. McCleary, L. E. M. Dunn, E. M. Charlton, C. Craig, B. Shih, T. Regan, R. M. Taylor, L. Sutherland, A. Gossner, C. Chintoan-Uta, , T. Burdon

The paper uses stem cell-derived macrophages from livestock to study host-pathogen interactions, showing they can be infected by important viruses and genetically modified.

bioRxiv · Sep 10, 2021Immunology

Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages

N. Kriplani, S. M. R. Clohisey, S. Fonseca, S. Fletcher, H.-M. Lee, J. Ashworth, D. Kurian, S. J. Lycett, C. Tait-Burkard, J. K. Baillie, M. E. J. Woolhouse, S. R. Carding, J. P. Stewart, P. Digard

This study shows that SARS-CoV-2 ORF8 protein modulates cytokine expression in human macrophages, with sequence polymorphisms affecting IL-6 and IL-8 secretion.

bioRxiv · Aug 13, 2021 · PreprintMicrobiology

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

C. J. Brereton, L. Yao, Y. Zhou, M. Vukmirovic, J. A. Bell, R. A. Ridley, E. Davies, L. S. N. Dean, O. G. Andriotis, F. Conforti, S. Mohammed, T. Wallis, A. Tavassoli, R. Ewing, A. Alzetani, , M. Jones

This study shows that pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis by promoting bone-type cross-linking and increasing tissue stiffness.

bioRxiv · May 11, 2021Cell Biology

PolyA-modulating antisense oligonucleotides reveal opposing functions for long non-coding RNA NEAT1 isoforms in neuroblastoma

A. Naveed, J. A. Cooper, R. Li, A. Hubbard, T. Liu, S. Wilton, S. Fletcher, A. Fox

The paper develops antisense oligonucleotides to modulate NEAT1 isoform ratios in neuroblastoma, showing increased NEAT1_2 and reduced cell viability.

Cellular and Molecular Life Sciences · Mar 1, 2021Peer-reviewedCancer Biology

Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells

I. McCracken, G. Saginc, L. He, A. Huseynov, A. Daniels, S. Fletcher, C. Peghaire, V. Kalna, M. A. Mae, L. Muhl, N. M. Craig, S. J. Griffiths, J. G. Haas, C. T. Burkard, U. Lendahl, , A. M. Randi

The paper investigates ACE2 expression and SARS-CoV-2 infection in human endothelial cells, finding low or absent ACE2 expression and no viral replication.

bioRxiv · Dec 2, 2020Pathology