W. Ge

Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma

This study identifies genomic heterogeneity and ploidy as markers of intrinsic resistance to PD-1 blockade in metastatic melanoma, with a decision tree model predicting resistance with high confidence.

A neurovascular progenitor sits at the nexus of glioblastoma lineage trajectories

This study identifies a neurovascular progenitor cell type in glioblastoma that links distinct malignant lineages and influences tumor composition and survival.

Human Organoid Tumor Transplantation Identifies Functional Glioblastoma - Microenvironmental Communication Mediated by PTPRZ1

The paper uses a human organoid tumor transplantation system to study glioblastoma-microenvironment interactions, identifying PTPRZ1 as a key mediator of intercellular communication.

The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species.

This paper identifies Erg6 as an essential gene for viability in Aspergillus species and shows its importance in fungal infection models.

Genetic Analysis of Activin/Inhibin β Subunits in Zebrafish Development and Reproduction

This study investigates the role of activin/inhibin β subunits in zebrafish development and reproduction, showing their critical role in folliculogenesis and ovarian homeostasis.

MicroRNA-27a-5p inhibits proliferation, migration and invasion and promotes apoptosis of Wilms tumor cell by targeting PBOV1

This study shows miR-27a-5p suppresses Wilms tumor by inducing apoptosis and inhibiting proliferation, migration, and invasion through targeting PBOV1.

DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

DIA-based Proteomics Identifies IDH2 as a Targetable Regulator of Acquired Drug Resistance in Chronic Myeloid Leukemia

This study identifies IDH2 as a targetable regulator of drug resistance in CML by analyzing proteomic changes in resistant K562 cells.

Gonadectomy and blood sampling procedures in small size teleost models

The paper describes a protocol for gonadectomy and blood sampling in small teleost fish, specifically medaka, to study sex steroid effects on physiology.

Daily mitochondrial dynamics in cone photoreceptors

The paper examines daily mitochondrial dynamics in zebrafish cone photoreceptors, finding increased mitochondrial biogenesis at night and structural changes during the day.

PulseDIA: in-depth data independent acquisition mass spectrometry using enhanced gas phase fractionation

PulseDIA improves DIA-MS specificity and sensitivity by using gas phase fractionation, achieving higher protein identification rates in cancer proteomics.

Mitochondrial Ca2+ influences photoresponse recovery, metabolism, and mitochondrial localization in cone photoreceptors

This study shows that low mitochondrial Ca2+ uptake in zebrafish cone photoreceptors affects photoresponse recovery, metabolism, and mitochondrial localization, with increased MCU expression altering these processes.

Systems Biology Understanding of the Effects of Lithium on Cancer.

The paper analyzes the mutual enrichment between lithium-sensitive enzymes and cancer pathways using STRING and KEGG databases, finding significant associations that support lithium's role in cancer.