S. Narayanan

Klebsiella pneumoniae Co-infection Leads to Fatal Pneumonia in SARS-CoV-2-infected Mice

This study shows that co-infection with SARS-CoV-2 and Klebsiella pneumoniae in mice leads to severe pneumonia and higher mortality.

Maximum Mutational Robustness in Genotype-Phenotype Maps Follows a Self-similar Blancmange-like Curve

The paper proves that maximum mutational robustness in genotype-phenotype maps follows a fractal sums-of-digits function and shows this bound is achieved by RNA secondary structure and HP model phenotypes.

Repression of Hypoxia-Inducible Factor-1 Contributes to Increased Mitochondrial Reactive Oxygen Species Production in Diabetes

This study shows that hyperglycemia represses HIF-1, leading to increased mitochondrial ROS production and renal injury in diabetes, which can be mitigated by restoring HIF-1 function.

Hypercholesterolemia Impairs Clearance of Extracellular DNA and Promotes Inflammation and Atherosclerotic Plaque Progression

This study shows hypercholesterolemia impairs DNA clearance by reducing DNase activity, leading to inflammation and atherosclerosis progression in mice and humans.

Evolution of Single Gyroid Photonic Crystals in Bird Feathers

The paper describes the evolution of single gyroid photonic crystals in bird feathers from ancestral quasi-ordered structures, highlighting their potential for multi-functional applications.

A dynamical extracellular matrix coat regulates moruloid-blastuloid transitions of ovarian cancer spheroids

This study shows that a dynamic extracellular matrix coat on ovarian cancer spheroids regulates their morphogenesis and adhesion to substrata, affecting metastasis.

LAG3 is a Central Regulator of NK Cell Cytokine Production

This study shows that LAG3 inhibits cytokine production in mature NK cells by enhancing glycolytic metabolism and is upregulated by IFN-.

Crystal structure of calcium bound outer membrane phospholipase A (OmpLA) from Salmonella typhi and in silico anti-microbial screening

The paper presents the crystal structure of Salmonella typhi OmpLA and identifies potential small molecules targeting it for anti-microbial development.

Sensory domain of the cell cycle kinase CckA in Caulobacter crescentus regulates the differential DNA binding activity of the master regulator CtrA

The paper identifies a mutation in CckA's PAS-B domain that increases CtrA phosphorylation but selectively enhances its binding to the origin of replication, Cori, in Caulobacter crescentus.