Author

S. Otsuka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Ecology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:electronic health records· 3 Approach:microscopy & imaging analysis· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

J. Ellenberg· 2 shared M. J. Hossain· 2 shared M. Kueblbeck· 2 shared A. Callegari· 1 shared A. Forer· 1 shared A. M. Steyer· 1 shared A. Rybina· 1 shared A. Sali· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

J. Ellenberg

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Author profile →

7 papers

Recent·Most cited

Structural evidence for elastic tethers connecting separating chromosomes in crane-fly spermatocytes

A. Forer, S. Otsuka

The paper uses live imaging and electron tomography to identify structural tethers connecting separating telomeres in crane-fly spermatocytes during meiosis I.

bioRxiv · May 28, 2023Cell Biology

The endoplasmic reticulum connects to the nucleus by constricted junctions that mature after open mitosis in mammalian cells

H. Bragulat-Teixidor, K. Ishihara, G. M. Szucs, S. Otsuka

This study examines the ultrastructure of ER-NE junctions in mammalian cells, revealing a constricted hourglass shape in interphase cells that emerges during telophase.

bioRxiv · Jan 31, 2023 · PreprintCell Biology

A chromatin phase transition protects mitotic chromosomes against microtubule perforation

M. W. G. Schneider, B. A. Gibson, S. Otsuka, M. F. D. Spicer, M. Petrovic, C. Blaukopf, C. C. H. Langer, L. K. Doolittle, M. K. Rosen, D. W. Gerlich

This study shows that global histone deacetylation during mitosis induces a chromatin phase transition that protects chromosomes from microtubule perforation and ensures proper segregation.

bioRxiv · Jul 5, 2021 · PreprintCell Biology

A quantitative map of nuclear pore assembly reveals two distinct mechanisms

S. Otsuka, J. O. B. Tempkin, W. Zhang, A. Z. Politi, A. Rybina, M. J. Hossain, M. Kueblbeck, A. Callegari, B. Koch, N. R. Morero, A. Sali, J. Ellenberg

The paper maps nuclear pore complex assembly in human cells, revealing two distinct molecular mechanisms with different orders of component addition.

bioRxiv · May 17, 2021Cell Biology

Epigenetic Effects of Exposure to Insecticide on Early Differentiation of Mouse Embryonic Stem Cells

W. Wang, S. Otsuka, H. Nansai, T. Ito, K. Abe, Y. Nakao, J. Ohgane, M. Yoneda, H. Sone

This study evaluates the effects of insecticides on DNA methylation during early mouse embryonic stem cell differentiation and identifies imidacloprid's potential developmental impact through altered methylation patterns.

bioRxiv · May 5, 2019Pharmacology & Toxicology

Soil nutrient stoichiometry affects the initial response of microbial community to trophic perturbation.

K. Mise, R. Maruyama, Y. Miyabara, T. Kunito, K. Senoo, S. Otsuka

The paper shows that soil phosphorus availability affects how microbial communities respond to carbon and nitrogen additions, with lower phosphorus soils showing prolonged effects.

bioRxiv · May 28, 2018Ecology

Postmitotic Nuclear Pore Assembly Proceeds By Radial Dilation Of Small ER Membrane Openings

S. Otsuka, A. M. Steyer, M. Schorb, J.-K. Heriche, M. J. Hossain, S. Sethi, M. Kueblbeck, Y. Schwab, M. Beck, J. Ellenberg

The paper shows that postmitotic nuclear pore assembly occurs through dilation of ER membrane openings, forming transport channels rapidly.

bioRxiv · Sep 21, 2017Cell Biology