Author

K. Knox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Animal Behavior & Cognition· 1 Biochemistry· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Roy· 2 shared G. Gottschalk· 2 shared K. Kesler· 2 shared M. Kala· 2 shared B. A. Bixby· 1 shared B. J. LaFleur· 1 shared B. Liu· 1 shared C. Bime· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersAnimal Behavior & Cognition

A. Roy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension

D. Yi, B. Liu, H. Ding, S. Li, R. Li, J. Pan, K. Ramirez, X. Xia, M. Kala, I. Singh, Q. Ye, W. H. Lee, R. Frye, T. Wang, Y. Zhao, , Z. Dai

This study shows that SOX17 deficiency in endothelial cells causes pulmonary hypertension via E2F1 signaling, suggesting E2F1 as a therapeutic target in PAH.

bioRxiv · Feb 15, 2023Physiology

T-cell cellular stress and reticulocyte signatures, but not loss of naive T lymphocytes, characterize severe COVID-19 in older adults

M. Jergovic, M. Watanabe, R. Bhat, C. P. Coplen, S. A. Sonar, R. Wong, Y. Castaneda, L. Davidson, M. Kala, R. C. Wilson, H. L. Twigg, K. Knox, H. E. Erickson, C. C. Weinkauf, C. Bime, , J. Z. Nikolich

The paper identifies T-cell stress and reticulocyte signatures as markers of severe COVID-19 in older adults, while showing naive T-cell decline is age-related, not disease-specific.

bioRxiv · Dec 21, 2022Immunology

Intranasal Administration of ACIS KEPTIDE™ Prevents SARS-CoV2-Induced Acute Toxicity in K18-hACE2 Humanized Mouse Model of COVID-19: A Mechanistic Insight for the Prophylactic Role of KEPTIDE™ in COVID-19

G. Gottschalk, J. F. Keating, K. Kesler, K. Knox, A. Roy

This paper shows that ACIS KEPTIDE prevents SARS-CoV2-induced toxicity and mortality in mice by reducing ACE-2 expression and viral entry.

bioRxiv · Nov 13, 2020 · PreprintAnimal Behavior & Cognition

ACIS, A Novel KepTide™, Binds to ACE-2 Receptor and Inhibits the Infection of SARS-CoV2 Virus in vitro in Primate Kidney Cells: Therapeutic Implications for COVID-19

A. Roy, G. Gottschalk, K. Knox, C. H. Luan, J. Keating, K. Kesler

bioRxiv · Oct 13, 2020 · PreprintBiochemistry