Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver
S. K. Masenga, A. C. Murphy, P. Venkhatesh, Z. Vue, A. A. Kadam, A. G. Marshall, B. I. Rodriguez, E. Scudese, B. C. Jenkins, A. Crabtree, P. Prasad, E. G. Lopez, H. Le, K. Actkins, E. Zaganjor, , C. P. H Perez
This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.
bioRxiv · Jun 20, 2024 · PreprintPhysiology