K. Feng

Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancer

This study identifies MMP1+ fibroblasts as a cellular determinant of resistance to PD-1 pathway blockade in NSCLC by analyzing single-cell RNA sequencing data and spatial architecture.

Elemental profiling and genome-wide association mapping reveal genomic variants modulating ionomic composition in Populus trichocarpa leaves

This study identifies genetic loci modulating ionomic composition in Populus trichocarpa leaves using GWAS and multi-platform ionome profiling.

GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

This study shows GABRD promotes breast cancer progression by regulating the cell cycle through CDK1 interaction.

The Plasminogen-Apple-Nematode (PAN) domain suppresses JA/ET defense pathways in plants

The study shows the PAN domain in G-type lectin receptor-like kinases suppresses JA/ET defense pathways in plants by promoting receptor degradation.

GWAS identifies candidate regulators of in planta regeneration in Populus trichocarpa

This study uses GWAS to identify candidate genes regulating in planta regeneration in Populus trichocarpa, finding over 200 genes involved in cell adhesion, stress signaling, and hormone pathways.

Core cysteine residues in the PAN domain are critical for HGF/c-MET signaling

This study identifies core cysteine residues in the PAN domain of HGF as essential for c-MET signaling, showing their role in receptor binding, phosphorylation, and downstream gene activation.

A parasite's paradise: Biotrophic species prevail oomycete community composition in tree canopies

This study shows that obligate biotrophic oomycetes dominate tree canopies, indicating canopies as a reservoir for parasitic protists and challenging previous assumptions about host dependencies.

On the phenology of protists: Recurrent patterns reveal seasonal variation of protistan (Rhizaria: Cercozoa, Endomyxa) communities in tree canopies

This study identifies seasonal patterns in protistan communities in tree canopies using high-throughput sequencing, revealing distinct taxa in spring and autumn and highlighting the canopy as a reservoir for wind-dispersed propagules.

What drives the assembly of plant-associated protist microbiomes?

The study investigates how soil type and plant species influence the assembly of Cercozoa protist communities in the rhizosphere, finding plant species has a stronger effect than soil type.

ATR Inhibitors as Potent Modulators of DNA End Resection Capacity

This study shows that long-term ATR inhibition reduces DNA end resection and DNA repair efficiency in cancer cells, offering a strategy to enhance PARP inhibitor sensitivity.