Author

H. Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 2 Physiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:imaging· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Organism:mouse· 4 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. Scudese· 4 shared Z. Vue· 4 shared A. Crabtree· 3 shared A. G. Marshall· 3 shared A. Kinder· 3 shared A. Kirabo· 3 shared D. Tomar· 3 shared E. Zaganjor· 3 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPhysiology

E. Scudese

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

S. K. Masenga, A. C. Murphy, P. Venkhatesh, Z. Vue, A. A. Kadam, A. G. Marshall, B. I. Rodriguez, E. Scudese, B. C. Jenkins, A. Crabtree, P. Prasad, E. G. Lopez, H. Le, K. Actkins, E. Zaganjor, , C. P. H Perez

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

bioRxiv · Jun 20, 2024 · PreprintPhysiology

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

P. Katti, P. Prasad, S. K. Masenga, P. Venkhatesh, Z. Vue, A. G. Marshall, B. Rodrageaz, H. Le, E. Garza-Lopez, A. Murphy, B. Jenkins, A. Kadam, J. Shao, A. Crabtree, P. Martin, , McReyn

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

bioRxiv · Jun 9, 2024Physiology

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

D. Doppler, A. Grieco, D. Koh, A. Manna, A. Ansari, R. Alvarez, K. Karpos, H. Le, M. Sonker, G. Ketawala, S. Mahmud, I. Quereda Moraleda, A. L. Pey, R. Letrun, K. Doerner, , A. Ros

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

bioRxiv · Apr 29, 2024Biochemistry

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2 Mediated Changes

E. Scudese, Z. Vue, P. Katti, A. Marshall, M. Demirci, L. Vang, E. Garza Lopez, K. Neikirk, H. Le, D. Stephens, D. D. Hall, R. Rostami, T. Rodman, K. Kabugi, J.-q. Shao, , A. Hinton

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

bioRxiv · Nov 13, 2023Biophysics

Quantitative Assessment of Morphological Changes in Lipid Droplets and Lipid-Mito Interactions with Aging in Brown Adipose

A. Crabtree, K. Neikirk, J. Pinette, A. Whiteside, B. Shao, J. McKenzie, Z. Vue, L. Vang, H. Le, M. Demirci, T. Ahmad, T. C. Owens, A. Oliver, F. Zeleke, H. K. Beasley, , A. Hinton

This study quantifies age-related changes in lipid droplet morphology and mitochondria-lipid interactions in murine brown adipose tissue using 3D imaging and analysis.

bioRxiv · Sep 23, 2023Biophysics

Nanoparticles targeted to fibroblast activation protein outperform PSMA for MRI delineation of primary prostate tumours

N. Dmochowska, V. Milanova, R. Mukkamala, K. K. Chow, N. T. Pham, M. Srinivasarao, L. M. Ebert, T. Stait-Gardner, H. Le, A. Shetty, M. Nelson, P. S. Low, B. Thierry

This study compares FAP-targeted MRI with PSMA-targeted MRI for delineating prostate tumors in mice, finding FAP provides better contrast enhancement.

bioRxiv · Jun 10, 2022 · PreprintBioengineering

Functional arrays of human pluripotent stem cell-derived cardiac microtissues

N. Thavandiran, C. Hale, P. Blit, M. L. Sandberg, M. E. McElvain, M. Gagliardi, B. Sun, A. Witty, G. Graham, M. McIntosh, M. A. Bakooshli, H. Le, J. Ostblom, S. McEwen, E. Chau, , P. Zandstra

This paper develops a 96-well platform of cardiac microtissues to measure contractile force for drug screening and tissue engineering.

bioRxiv · Mar 5, 2019Bioengineering