S. Simon

Dominance modifiers at the Arabidopsis self-incompatibility locus retain proto-miRNA features and act through non-canonical pathways

The paper investigates sRNA precursors at the Arabidopsis self-incompatibility locus, showing they repress recessive alleles through non-canonical pathways and generate diverse sRNA molecules.

Phylogenomics recovers multiple origins of portable case-making in caddisflies (Insecta: Trichoptera), the world's most common underwater architects

This study uses phylogenomic data to reconstruct the evolutionary history of caddisflies, finding that portable case-making evolved independently in three lineages.

Microbial fingerprints reveal interaction between museum objects, curators and visitors

The paper uses microbial signatures from museum objects to identify human contact patterns and differentiate between individuals' touch.

Through the Random Forest: Ontogeny as a study system to connect prediction to explanation

The paper uses random forest models to analyze an ontogenetic consumer-resource model, revealing ecological mechanisms that influence stability.

Computational Analysis of Effects of Clot Length on Acute Ischemic Stroke Recanalization under Different Cyclic Aspiration Loading Conditions

This study uses finite element simulations to analyze how clot length affects recanalization during cyclic aspiration, revealing failure mechanisms and potential endothelial damage.

Dual blockade of misfolded alpha-sarcoglycan degradation by bortezomib and givinostat combination

This study identifies givinostat as a potential therapeutic for LGMD R3 by inhibiting autophagy and enhancing bortezomib's effect on misfolded alpha-sarcoglycan degradation.

Impact of pre-breeding feeding practices on rabbit mammary gland development at mid-pregnancy.

This study examines how different feeding strategies during early life affect mammary gland development in rabbits at mid-pregnancy, finding impacts on metabolic parameters and mammary tissue structure.

Deep Mutational Engineering of broadly-neutralizing and picomolar affinity nanobodies to accommodate SARS-CoV-1 & 2 antigenic polymorphism

This study engineers nanobodies with picomolar affinity and broad neutralizing activity against SARS-CoV-1 and SARS-CoV-2 variants using Deep Mutational Engineering.

The effect of mating complexity on gene drive dynamics

This study examines how mating complexities affect gene drive dynamics, finding that mate-choice, mating systems, and spatial networks significantly influence spread rates and effectiveness.

Large-scale geographic survey provides insights into the colonization history of a major aphid pest on its cultivated apple host in Europe, North America and North Africa

The paper investigates the colonization history of the rosy apple aphid across Europe, North America, and North Africa using genetic and microbiota data, finding weak genetic differentiation and limited role of secondary endosymbionts in its spread.

Rapid Detection of VanA/B-Producing Vancomycin-Resistant enterococci using Lateral Flow Immunoassay from colonies and blood culture

This paper evaluates a lateral flow immunoassay for rapid detection of VanB-producing vancomycin-resistant enterococci with 100% sensitivity and specificity.

Mutually opposing activity of PIN7 splicing isoforms is required for auxin-mediated tropic responses in Arabidopsis thaliana

The paper shows that PIN7 splicing isoforms PIN7a and PIN7b have opposing activities essential for auxin-mediated tropic responses in Arabidopsis thaliana.

Vpr Co-assembles with Gag during HIV-1 Assembly

This study shows Vpr co-assembles with Gag during HIV-1 assembly with a slight delay, confirming Vpr recruitment occurs during active Gag assembly rather than at the start.

Can genome-based analysis be the new gold-standard for routine Salmonella serotyping?

This study evaluates genome-based in silico serotyping for Salmonella using SeqSero and MLST, finding high concordance with classical serotyping but needing refinement for monophasic variants.

Phylogenetic synecdoche demonstrates optimality of subsampling and improves recovery of the Blaberoidea phylogeny

The paper optimizes subsampling in phylogenetic analysis to improve tree quality and reduce computational costs for Blaberoidea cockroaches.

Structures of the PKA RIα holoenzyme with the FLHCC driver J-PKAcα or wild type PKAcα

This paper reports the crystal structures of J-PKAc fusion and wild-type PKA holoenzymes, revealing structural differences and conformational dynamics that may impact their function in FLHCC.

CagY-dependent regulation of type IV secretion in Helicobacter pylori is associated with alterations in integrin binding

This study shows that recombination in the CagY MRR of H. pylori modulates T4SS function by altering binding to 5β1 integrin, which affects host inflammatory responses and bacterial colonization.