Author

S. Tovanabutra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:CUT&Tag· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Ananworanich· 3 shared L. A. Eller· 3 shared M. L. Robb· 3 shared N. L. Michael· 3 shared N. Phanuphak· 3 shared D. Hsu· 2 shared D. King· 2 shared E. Kroon· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

J. Ananworanich

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Author profile →

5 papers

Recent·Most cited

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype

M. H. Marichannegowda, S. Setua, M. Bose, E. Sanders-Buell, D. King, M. Zemil, L. Wieczorek, F. Diaz-Mendez, N. Chomont, R. Thomas, L. Francisco, L. A. Eller, V. R. Polonis, S. Tovanabutra, Y. Tagaya, , H. Song

The paper identifies an X4-tropic HIV-1 transmitted/founder virus in a person with wild-type CCR5, showing faster CD4 depletion and resistance to certain bNAbs.

bioRxiv · Sep 15, 2023Microbiology

Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting

M. H. Marichannegowda, M. Zemil, L. Wieczorek, E. Sanders-Buell, M. Bose, A. M. O'Sullivan, D. King, L. Francisco, F. Diaz-Mendez, S. Setua, N. Chomont, N. Phanuphak, J. Ananworanich, D. Hsu, S. Vasan, , H. Song

The paper tracks the coreceptor switch of HIV-1 in early infection, finding that a single mutation can drive X4 variants and co-evolution of antigenicity and tropism.

bioRxiv · Jan 21, 2023 · PreprintMicrobiology

Productive and latent HIV infections originate in resting CD4+ T cells

S. Wietgrefe, J. Anderson, L. Duan, P. J. Southern, P. Zuck, G. Wu, B. Howell, C. Reilly, E. Kroon, S. Chottanapund, S. Buranapraditkun, C. Sacdalan, N. Tulmethakaan, D. J. Colby, N. Chomchey, , A. T. Haase

This study shows that resting CD4+ T cells are the initial source of both productive and latent HIV infections in the earliest stages of detectable infection.

bioRxiv · Aug 26, 2022 · PreprintImmunology

A Remarkable Genetic Shift in a Transmitted/Founder Virus Broadens Antibody Responses Against HIV-1

S. Jain, G. Uritskiy, M. Mahalingam, H. Batra, S. Chand, H. Trinh, C. Beck, W.-H. Shin, W. AlSalmi, G. Kijak, L. A. Eller, J. Kim, D. Kihara, S. Tovanabutra, G. Ferrari, , V. B. Rao

The paper identifies a genetic shift in an HIV-1 transmitted/founder virus that leads to broader antibody responses by altering the V2 domain structure.

bioRxiv · Jun 16, 2021Microbiology

Dendritic cells focus CTL responses toward highly conserved and topologically important HIV epitopes

T. M. Garcia-Bates, M. L. Palma, D. C. HSU, J. Ananworanich, B. T. Korber, G. D. Gaiha, N. Phanuphak, R. Thomas, S. Tovanabutra, B. D. Walker, J. W. Mellors, P. A. Piazza, E. Kroon, S. A. Riddler, N. L. Michael, , R. B. Mailliard

This study uses dendritic cells to focus CD8+ T cell responses on conserved and topologically important HIV epitopes to prevent immune escape.

bioRxiv · Jul 13, 2020Immunology