M. L. Robb

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype

The paper identifies an X4-tropic HIV-1 transmitted/founder virus in a person with wild-type CCR5, showing faster CD4 depletion and resistance to certain bNAbs.

Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting

The paper tracks the coreceptor switch of HIV-1 in early infection, finding that a single mutation can drive X4 variants and co-evolution of antigenicity and tropism.

Productive and latent HIV infections originate in resting CD4+ T cells

This study shows that resting CD4+ T cells are the initial source of both productive and latent HIV infections in the earliest stages of detectable infection.

HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections

This study identifies that HIV initially infects diverse CD4+ T cells in blood and lymph nodes, establishing both productive infections and latent reservoirs simultaneously.

Boosting with ALVAC-HIV and AIDSVAX B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity

The paper shows that boosting RV144 vaccine recipients with ALVAC-HIV and AIDSVAX B/E increases C1C2-specific antibody-dependent cellular cytotoxicity breadth and potency.

Global variability of the human IgG glycome

The paper analyzes global variability in IgG glycosylation across populations, finding that country of residence and socioeconomic development strongly influence glycan features and monogalactosylation levels.