D. Hsu

Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting

The paper tracks the coreceptor switch of HIV-1 in early infection, finding that a single mutation can drive X4 variants and co-evolution of antigenicity and tropism.

Arginine limitation causes a directed DNA sequence evolution response in colorectal cancer cells

This study shows that arginine limitation in colorectal cancer cells drives DNA sequence evolution away from arginine codons, leading to altered proteins.

Productive and latent HIV infections originate in resting CD4+ T cells

This study shows that resting CD4+ T cells are the initial source of both productive and latent HIV infections in the earliest stages of detectable infection.

Chromatin Remodeling in Patient-Derived Colorectal Cancer Models

This study compares chromatin remodeling in colorectal cancer patient-derived models and identifies transcription factors driving differences in growth and drug response.

HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections

This study identifies that HIV initially infects diverse CD4+ T cells in blood and lymph nodes, establishing both productive infections and latent reservoirs simultaneously.

Two Isoleucyl tRNAs that Decode 'Synonymous' Codons Divergently Regulate Breast Cancer Progression

The paper shows that two isoleucyl tRNAs decode synonymous codons and have opposing effects on breast cancer progression by regulating translation of growth-promoting genes.

A cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma

This study develops a cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma, finding that dual inhibition of proteasome and CRM1 pathways induces synergistic cytotoxicity.

Dietary methionine restriction targets one carbon metabolism in humans and produces broad therapeutic responses in cancer

This study shows that dietary methionine restriction affects one carbon metabolism in humans and produces therapeutic responses in cancer by altering metabolic pathways.