S.-C. Kim

Identification of phospholipase Ds and phospholipid species involved in circadian clock alterations using CRISPR/Cas9-based multiplex editing of Arabidopsis

This study identifies combinations of two or more phospholipase Ds and specific phosphatidic acid species involved in altering circadian clock outputs in Arabidopsis.

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

Circadian clock factors regulate seed oil accumulation by promoting fatty acid synthesis in Arabidopsis

This study shows that circadian clock factors LHY and CCA1 regulate seed oil accumulation in Arabidopsis by enhancing fatty acid synthesis through activation of the KASIII gene.

Lipid-mediated nuclear moonlighting of cytosolic glyceraldehyde-3-phosphate dehydrogenase in plant heat response

The paper shows that phosphatidic acid, produced by phospholipase Dδ, mediates the nuclear translocation of cytosolic GAPC under heat stress in plants.

Therapeutic base and prime editing of COL7A1 mutations in recessive dystrophic epidermolysis bullosa

This study corrects COL7A1 mutations in RDEB patient fibroblasts using base and prime editing, restoring C7 expression and function in vitro and in vivo.