S. Bae

Spatial transcriptomics unveils landscape of resistance to concurrent chemo-radiotherapy in hypopharyngeal squamous cell carcinoma: the role of SPP1+ macrophages

This study uses spatial transcriptomics to identify SPP1+ macrophages as key contributors to CCRT resistance in hypopharyngeal SCC by modulating the tumor microenvironment.

From expert opinion to empirical evidence: Data-driven parametrization of urban connectivity models using movement-proxy data

This paper develops a data-driven framework to parametrize urban connectivity models using movement-proxy data, finding that empirical parameters improve model performance compared to expert-based estimates.

Detection of Blood Volume Reduction and Vasoconstriction Following Focused Ultrasound Blood-Brain Barrier Opening Using Ultrasound Flow Imaging

This study uses ultrasound flow imaging to detect blood volume reduction and vasoconstriction after FUS-induced BBB opening in mice.

A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer

This paper introduces ADT-007, a novel pan-RAS inhibitor that effectively blocks tumor growth in mouse models of GI cancer by targeting RAS activation and inducing apoptosis.

Lectin-Seq: a method to profile lectin-microbe interactions in native communities

Lectin-Seq profiles lectin-microbe interactions in human fecal microbiota, revealing distinct binding preferences for MBL and hItln1.

IMPASTO: Multiplexed cyclic imaging without signal removal via self-supervised neural unmixing

IMPASTO enables erasureless cyclic imaging for multiplexed spatial proteomics through self-supervised neural unmixing, achieving 30-plex imaging with reduced tissue distortion.

Existence of blood circulating immune-cell clusters (CICs) comprising antigen-presenting cells and B cells

The paper identifies circulating immune-cell clusters (CICs) composed of antigen-presenting cells and B cells in blood, showing increased frequency in COVID-19 patients.

One-step pipetting of barcoded planar microparticles into compact monolayer assembling chip for efficient readout of multiplexed immunoassay

The paper presents a microfluidic chip for efficient multiplexed immunoassay readout using barcoded planar microparticles, achieving good accuracy with a single pipetting step.

Robust hydrogel-integrated microsystems enabled by enhanced interfacial bonding strength

This paper introduces a mucosa-inspired bonding method to enhance the mechanical robustness of noncovalent hydrogels by bonding them to tough hydrogels without chemical modification.

In vivo mitochondrial matrix proteome profiling reveals RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase

The paper uses a transgenic mouse model to profile mitochondrial matrix proteomes and identifies RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase involved in CoQ biosynthesis and mitochondrial function.

Therapeutic base and prime editing of COL7A1 mutations in recessive dystrophic epidermolysis bullosa

This study corrects COL7A1 mutations in RDEB patient fibroblasts using base and prime editing, restoring C7 expression and function in vitro and in vivo.

Human gut bacteria produce TH17-modulating bile acid metabolites

This study identifies human gut bacteria that produce TH17-modulating bile acid metabolites, showing reduced levels in IBD patients.

A Bacterial Bile Acid Metabolite Modulates Treg Activity through the Nuclear Hormone Receptor NR4A1

This study identifies a bacterial bile acid metabolite, isoalloLCA, that enhances Treg cell differentiation via NR4A1 and is reduced in inflammatory bowel disease patients.

Newly developed silicone airway stent (GINA stent): Mechanical characteristics and performance evaluation in pigs

The paper evaluates a new silicone airway stent (GINA stent) in pigs, showing improved mechanical properties and comparable performance to the Dumon stent.

Ex vivo therapeutic base and prime editing using chemically derived hepatic progenitors in a mouse model of tyrosinemia type 1

This study corrects a disease-causing mutation in a mouse model of tyrosinemia type 1 using ex vivo base and prime editing with chemically derived hepatic progenitors, improving survival rates.

Rapid Establishment of Tracheal Stenosis in Pigs Using Endotracheal Tube Cuff Overpressure and Electrocautery

This paper develops a rapid tracheal stenosis model in pigs using cuff overpressure and electrocautery, achieving stenosis in 7 days with combined treatment.

Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPσ

This study determines the structural basis of SALM3 dimerization and its interaction with PTPσ, showing that dimerization is required for synaptogenic activity.

CRISPR-Cas9 screening of KSHV-transformed cells identifies XPO1 as a vulnerable target of cancer cells

This study identifies XPO1 as a vulnerable target in cancer cells using CRISPR-Cas9 screening in KSHV-transformed cells, showing its role in cell proliferation and growth transformation.