Author

T. Conrad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:differential expression· 4 Organism:human· 4 Assay:scRNA-seq· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:mouse· 3 Approach:statistical model· 3

Frequent Co-Authors

B. Siegmund· 2 shared A. A. Brakhage· 1 shared A. A. Kuehl· 1 shared A. Eggert· 1 shared A. G. Henssen· 1 shared A. L. Nguyen· 1 shared A. Leutz· 1 shared A. Medyukhina· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

B. Siegmund

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Osteopontin in colitis-associated carcinoma

S. Manna, M. Sehn, D. Cardoso da Silva, J. J. Wiese, C. Heldt, I. Plumbom, T. Conrad, C. C. Husemann, K. Kleo, L. Derezanin, V. Dony, S. K. Farahani, F. Weiss, A. A. Kuehl, S. Schallenberg, , M. Schumann

This study investigates the role of osteopontin (SPP1/OPN) in colitis-associated carcinoma (CAC) using a multi-omics approach, revealing its indirect immunosuppressive role in the tumor microenvironment.

bioRxiv · Dec 15, 2023 · PreprintCancer Biology

Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in patients with inflammatory bowel disease

V. Horn, C. Cancino, L. Steinheuer, B. Obermayer, K. Fritz, A. L. Nguyen, C. Plattner, D. Boesel, M. Burns, A. R. Schulz, E. Mantzivi, D. Lissner, T. Conrad, M.-F. Mashreghi, E. Sonnenberg, , A. N. Hegazy

bioRxiv · Oct 1, 2023Immunology

In situ Patch-seq analysis of microglia reveals a lack of stress genes as found in FACS-isolated microglia

O. Bakina, T. Conrad, N. Mitic, R. O. Vidal, T. Obrusnik, S. Sai, C. Nolte, M. Semtner, H. Kettenmann

The paper uses patch-seq to analyze microglia in situ and finds they lack stress-related genes compared to FACS-isolated microglia.

bioRxiv · Mar 22, 2023 · PreprintImmunology

Intercellular extrachromosomal DNA copy number heterogeneity drives cancer cell state diversity

M. C. Stoeber, R. Chamorro Gonzalez, L. Brueckner, T. Conrad, N. Wittstruck, A. Szymansky, A. Eggert, J. H. Schulte, R. P. Koche, A. G. Henssen, R. F. Schwarz, K. Haase

The paper investigates how ecDNA copy number heterogeneity affects gene expression and transcriptional states in neuroblastoma cells using single-cell DNA and RNA sequencing.

bioRxiv · Jan 21, 2023Cancer Biology

Tongue immune compartment analysis reveals spatial macrophage heterogeneity

A. Mildner, E. M. Lyras, K. Zimmermann, L. K. Wagner, D. Dörr, C. Fischer, S. Jung, S. Yona, A.-H. Hovav, W. Stenzel, S. Dommerich, T. Conrad, A. Leutz

This study identifies two distinct macrophage subsets in the murine tongue using single-cell RNA-sequencing and in situ immunophenotyping, revealing their spatial distribution and differential responses to systemic LPS.

bioRxiv · Feb 9, 2022Immunology

Breaking the Crosstalk of the Cellular Tumorigenic Network in NSCLC by a Highly Effective Drug Combination

D. Guergen, T. Conrad, M. Becker, S. Sebens, C. Roecken, J. Hoffmann, S. Langhammer

This study shows a low-dose drug combination effectively suppresses NSCLC PDX tumors with high response and complete remission rates.

bioRxiv · Oct 23, 2021 · PreprintCancer Biology

Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus

I. A. Shopova, I. Belyaev, P. Dasari, S. Jahreis, M. C. Stroe, Z. Cseresnyes, A.-K. Zimmermann, A. Medyukhina, C.-M. Svensson, T. Krueger, V. Szeifert, S. Nietzsche, T. Conrad, M. G. Blango, O. Kniemeyer, , A. A. Brakhage

This study identifies antifungal extracellular vesicles (afEVs) released by human neutrophils in response to Aspergillus fumigatus, which associate with fungal cells and reduce growth through antimicrobial cargo.

bioRxiv · Dec 24, 2019Microbiology